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Aga Khan University

Brain and Mind Institute

Epidemiology

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Residential Proximity To Major Roadways Is Associated With Increased Levels Of Ac133+ Circulating Angiogenic Cells, Natasha Dejarnett, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James Mccracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, Jasmit Shah Nov 2015

Residential Proximity To Major Roadways Is Associated With Increased Levels Of Ac133+ Circulating Angiogenic Cells, Natasha Dejarnett, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James Mccracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, Jasmit Shah

Brain and Mind Institute

OBJECTIVES: Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.

APPROACH AND RESULTS: In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding …


Residential Proximity To Major Roadways Is Associated With Increased Levels Of Ac133+ Circulating Angiogenic Cells, Dejarnett Natasha, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James Mccracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, Jasmit Shah Aug 2015

Residential Proximity To Major Roadways Is Associated With Increased Levels Of Ac133+ Circulating Angiogenic Cells, Dejarnett Natasha, Ray Yeager, Daniel J. Conklin, Jongmin Lee, Timothy E. O’Toole, James Mccracken, Wes Abplanalp, Sanjay Srivastava, Daniel W. W. Riggs, Jasmit Shah

Brain and Mind Institute

Objectives: Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.

Approach and Results: In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding …