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Isolation And Characterization Of A B-D-Glucuronidase-Producing Strain Of Escherichia Coli Serotype O157:H7 In The United States, Peggy S. Hayes, Kristina Blom, Peter Feng, Jay Lewis, Nancy A. Strockbine, Bala Swaminathan
Isolation And Characterization Of A B-D-Glucuronidase-Producing Strain Of Escherichia Coli Serotype O157:H7 In The United States, Peggy S. Hayes, Kristina Blom, Peter Feng, Jay Lewis, Nancy A. Strockbine, Bala Swaminathan
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A phenotypic variant of Escherichia coli serotype O157:H7 (G5101) was isolated from a patient with bloody diarrhea. Strain G5101 does not ferment sorbitol but is β-D-glucuronidase and urease positive. Serotyping and colony hybridization using a serotype-specific DNA probe confirmed that the isolate was O157:H7. G5101 produces Shiga-like toxins I and II and contains an eae gene that is highly conserved in the O157:H7 serotype. This strain would have been missed by laboratories that screen for the sorbitol-negative, β-D-glucuronidase- negative phenotype in isolating E. coli O157:H7 from clinical and food specimens.
Genetic Polymorphism Of The Ipah Multicopy Antigen Gene In Shigella Spps. And Enteroinvasive Escherichia Coli, Jerry M. Buysse, Antoinette B. Hartman, Nancy Strockbine, Malabi Venkatesan
Genetic Polymorphism Of The Ipah Multicopy Antigen Gene In Shigella Spps. And Enteroinvasive Escherichia Coli, Jerry M. Buysse, Antoinette B. Hartman, Nancy Strockbine, Malabi Venkatesan
Public Health Resources
The ipaH loci comprise a multicopy antigen gene family unique to Shigella species and enteroinvasive Escherichia coli (EIEC). DNA probes derived from the Shigella flexneri stereotype 5 ipaH7.8 gene were used to compare the molecular arrangement of ipaH alleles in a variety of Shigella and EIEC strains. Multiple copies of ipaH-homologous sequences were detected in all invasion plasmids examined. Oligonucleotide probes covering discrete 24 bp segments of the ipaH7.8 gene and sequences flanking the ipaH4.5 (probe H25) and ipaH2.5 (probe H24) loci were used to define the extent of homology among invasion plasmid copies of …
Fulminant Hepatic Failure: Summary Of A Workshop, Jay Hoofnagle, Robert Carithers Jr., Craig Shapiro, Nancy Ascher
Fulminant Hepatic Failure: Summary Of A Workshop, Jay Hoofnagle, Robert Carithers Jr., Craig Shapiro, Nancy Ascher
Public Health Resources
Fulminant hepatic failure (FHF) is defined by the appearance of severe liver injury with hepatic encephalopathy in a previously healthy person. There are an estimated 2,000 cases of FHF in the United States yearly, representing 0.1% of all deaths and, perhaps, 6% of liver related deaths. The causes of FHF are many, the chief ones in the United States being hepatitis A; B; non-A, non-B and drug induced liver disease. There are no specific therapies for FHF, however, liver transplantation is recommended for situations in which spontaneous recovery appears unlikely. Factors that are valuable in assessing the likelihood of spontaneous …