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Glial Cell Alterations In The Rat Medial Preoptic Area And Hippocampus As A Function Of Reproductive State, Gordon Wentworth Gifford
Glial Cell Alterations In The Rat Medial Preoptic Area And Hippocampus As A Function Of Reproductive State, Gordon Wentworth Gifford
Master's Theses
Changes in reproductive state are accompanied by fluctuating levels of female gonadal hormones at higher levels and for longer periods of time than the normal estrus cycle. These hormones have been noted, in cell culture and over the regular estrus cycle, to influence structural changes in neurons and glial cells in areas of the brain associated with the conduct of maternal behavior. The purpose of this project was to characterize changes in GFAP immunoreactivity and astrocyte morphology in the mPOA and hippocampus as a function of reproductive state and female steroid hormone treatment. Results of this investigation noted an increases …
Modifications Of Nitric Oxide And Sexual Behavior In Prenatally Stressed Male Rats, Stephen D. Miller
Modifications Of Nitric Oxide And Sexual Behavior In Prenatally Stressed Male Rats, Stephen D. Miller
Master's Theses
Normal male sexual differentiation is the culmination of perfectly timed, prenatal gonadal hormone release. Prenatal stress (PS) has a detrimental effect upon this process, obstructing the natural development of brain structures and sexual behavior. Prenatally-stressed male rats exhibit many physiological and neuroendocrinological differences when compared to control males. PS has a particularly harmful effect upon male sexual behavior, to which the neurotransmitter nitric oxide (NO) has been shown to be intimately involved. The present experiment examined whether PS reduces nNOS, the rate limiting enzyme of NO, in the medial preoptic area (rnPOA) of male rats, and whether administration of the …