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The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson
The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson
Theses and Dissertations
There is a growing consensus, based on several converging lines of evidence, which suggests schizophrenia is the product of a developmental insult occurring in the late 2 nd or early 3 rd trimester. Additionally, it has been observed that adults who abuse the noncompetitive NMDA antagonist PCP present with symptoms that mimic schizophrenia, such as hallucinations, formal thought disorder, delusions, unstable or flattened affect, social withdrawal, and impaired cognition. Thus, several labs have attempted to use early postnatal PCP administration in rodents as a drug model of schizophrenia. The current study investigated the cognitive effects of early postnatal PCP administration …
Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting
Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting
Theses and Dissertations
Memory impairment is common following traumatic brain injury (TBI). In recent years, researchers have demonstrated that the processes underlying memory formation (working memory, encoding, consolidation, and retrieval) are interrelated but dissociable events.The following study was designed to determine how these processes contribute to memory impairment following experimental TBI in the rat. Experiment 1 indicated thatTBI induces severe working memory deficits in a delayed non-matching-to-place task.Although all animals displayed intact acquisition, only injured animals displayed poor performance as the delay between the sample and choice phases was increased.Experiment 2 was designed to determine if TBI produces a transient period of posttraumatic …
Parental Memory Predictors Of Children's Daily Diabetes Management And Metabolic Control, Sheryl J. Kent
Parental Memory Predictors Of Children's Daily Diabetes Management And Metabolic Control, Sheryl J. Kent
Theses and Dissertations
This study examined, for the first time, specific links between parents' memory and children's diabetes behaviors and metabolic control. Data revealed that parental memory and responsibility predicted children's percentage of calories from fat and carbohydrates, and metabolic control, accounting for 7.3% of the variance in calories from fat and 18.5% of the variance in metabolic control for the total sample. These effects were stronger when limited to dietary behaviors of younger youth; parental memory accounted for 30.3% and 33.6% of the variance in percentage of calories from fat and carbohydrates, respectively, for younger children. Level of parent responsibility, with memory, …
Memory Matters Ii: Predictors Of Self-Care Behaviors In Young Adults With Type 1 Diabetes, Sari A. Soutor
Memory Matters Ii: Predictors Of Self-Care Behaviors In Young Adults With Type 1 Diabetes, Sari A. Soutor
Theses and Dissertations
Type 1 diabetes and associated hypoglycemia can result in verbal memory difficulties, yet the role of memory in daily diabetes self-care has not been evaluated for young adults. Subtests from two well-standardized memory measures were administered to 34 young adults with type 1 diabetes, aged 18-29, in this pilot study. Self-care behaviors were assessed through 24-hour diabetes care interviews, while HbAlc indicated metabolic control. Verbal associative memory uniquely accounted for 12% of the variance in blood glucose testing frequency (p p p p = .06. Single-trial verbal memory uniquely predicted 10% of the variance in metabolic control (p p < .05. Importantly, memory was the only significant predictor in each model, which indicates memory, rather than overall cognitive capacity or financial/educational resources, relates to self-care behaviors/health status. Memory, a novel factor not previously evaluated in the quest to better understand daily disease management for young adults with diabetes, is significantly related to central self-care behaviors and metabolic control. Memory predictors likely warrant additional research and clinical attention such that eventually, intervention studies might identify strategies or compensatory aids that could improve young adults' self-care behaviors and health status through facilitating better memory functioning.