Digital Commons Network^™

Neural Substrates Of Fear Generalization And Its Associations With Anxiety And Intolerance Of Uncertainty, Ashley Ann Huggins

Theses and Dissertations

Fear generalization - the tendency to interpret ambiguous stimuli as threatening due to perceptual similarity to a learned threat – is an adaptive process. Overgeneralization, however, is maladaptive and has been implicated in a number of anxiety disorders. Neuroimaging research has indicated several regions sensitive to effects of generalization, including regions involved in fear excitation (e.g., amygdala, insula) and inhibition (e.g., ventromedial prefrontal cortex). Research has suggested several other small brain regions may play an important role in this process (e.g., hippocampal subfields, bed nucleus of the stria terminalis [BNST], habenula), but, to date, these regions have not been examined …

Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer

Theses and Dissertations

The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …

Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward

Theses and Dissertations

The ability to effectively withhold an inappropriate response is a critical feature of cognitive control. Prior research indicates alterations in neural processes required for motor response inhibition in anxious individuals, including those with posttraumatic stress disorder (PTSD), and those who engage in regular cannabis use. However, thus far most research has examined how anxiety-related symptoms and cannabis use influence response inhibition in isolation of one another. The current study examined the interactions between anxious symptomology and recent cannabis use in a sample that recently experienced a traumatic event using functional magnetic resonance imaging (fMRI) during the completion of a Stop-Signal …

Prolonged Distress In Residents Exposed To A Technological Disaster, Lindsey S. Hieber

Theses and Dissertations

This study investigated the prolonged emotional and behavioral effects of an ongoing technolog-ical disaster, the Flint Water Crisis. Past research indicates that surviving a technological disaster may have prolonged effects, including stress related disorders, even after the initial exposure pe-riod has passed. The survey consisted of questions involving knowledge of the effects of lead and Legionnaires’ disease as well as questions regarding how to use water filters properly, ques-tions modeled after the Health Belief Model, behavioral changes, and an anxiety, stress, and de-pression scale. Additionally, there were questions asking participants how well they feel the crisis was handled, how much …

Investigation Of The Relationship Between Mindfulness And Empathy In Pre-Nursing Students Exposed To A Four-Week Mindfulness Training, Debra L. Klich

Theses and Dissertations

Objective: To investigate the effects of a four-week mindfulness program on levels of mindfulness, empathy, and anxiety in a group of pre-nursing students.

Methods: This study utilized a multiple-baseline across subjects design. Results from nine study participants were examined.

Results: Data demonstrates that a detectable decrease in anxiety levels can result from participation in self-directed mindfulness program as short as four weeks. Results regarding mindfulness and empathy levels were less conclusive. A specific relationship between empathy and mindfulness cannot be determined from this study.

Conclusions: Because previous studies have demonstrated a persistence of skills, practice, and benefits acquired through mindfulness …

How Does Anxiety Affect Cognitive Control? Proactive And Reactive Control Under State Anxiety, Youcai Yang

Theses and Dissertations

Cognitive control is a construct that prioritizes how we process stimuli and information and execute behaviors to flexibly and efficiently adapt to internal goals and external environmental changes. A recent theory, the Dual Mechanism of Control (DMC), distinguishes this phenomenon by two distinct cognitive control operations: proactive control and reactive control (Braver, 2012). Anxiety increases the allocation of attentional and working memory resources to threat-related stimuli, which impairs cognitive performance (Sarason, 1988), but additional work is needed to assess how anxiety impacts these two distinct forms of cognitive control. In this study, I examined how state anxiety affected proactive control, …

Moderating Effects Of Harm Avoidance On Resting-State Functional Connectivity Of The Anterior Insula, Ashley Ann Huggins

Theses and Dissertations

As an index of behavioral inhibition and an individual’s propensity to avoid, rather than seek, potentially dangerous situations, harm avoidance has been linked to internalizing psychopathology. Altered connectivity within intrinsic functional neural networks has been linked to internalizing psychopathology; however, less is known about the effects of harm avoidance on functional connectivity within and between these networks. Importantly, harm avoidance may be distinguishable from trait anxiety and have clinical relevance as a risk factor for psychopathology. To this end, the current study aimed to examine associations between harm avoidance and resting state functional connectivity. A sample of undergraduate students (n=92) …

If Or When? Uncertainty's Role In Anxious Anticipation, Kenneth P. Bennett

Theses and Dissertations

Uncertainty is often associated with subjective distress and a potentiated anxiety response. Occurrence uncertainty (OU), or the inability to predict if a threat will occur, has never been compared experimentally with temporal uncertainty (TU), or the inability to predict when a threat will occur. The current study aimed to 1) directly compare the eye-blink startle responsivity of OU and TU, 2) develop a more effective task for isolating uncertain anticipation, and 3) better understand the relationship between individual differences in the intolerance of uncertainty and uncertain anticipation startle responsivity. The novel study showed that OU anticipation is more anxiety provoking …

Neural Circuitry Underlying The Intrusion Of Task-Irrelevant Threat Into Working Memory In Anxiety, Daniel Stout

Theses and Dissertations

Dispositional anxiety is an important risk factor for the development of anxiety and other psychological disorders. Symptoms commonly expressed by highly anxious individuals include intrusive memories, uncertainty, and worry — all occurring in the absence of immediate threat. This raises the possibility that anxious individuals have difficulty governing threat’s access to working memory, the mental workspace where goal-related information is actively retained for guiding on-going behavior. Using functional magnetic resonance imaging (fMRI) while 81 subjects completed a well-validated working memory task, I show that threat-related and neutral distracters unnecessarily gain access to working memory, as evidenced by increased neural activity …

Neural Plasticity Of Extinction: Relations With Anxiety And Extinction Retention, Emily Louise Belleau

Theses and Dissertations

ABSTRACT

NEURAL PLASTICITY OF EXTINCTION LEARNING: RELATIONS WITH ANXIETY AND EXTINCTION RETENTION

by

Emily L. Belleau

The University of Wisconsin-Milwaukee, 2016

Under the Supervision of Associate Professor Christine Larson

Anxiety is a significant public health problem characterized by substantial psychological, physical, and economic burden. A key feature of anxiety is the inability to regulate fear. Aberrant extinction of conditioned fear is one prominent model of the etiology of anxiety disorders. Previous studies have shown that the neural circuitry underlying anxiety pathology overlaps with that mediating fear extinction learning. Recently, more precise pathways supporting the expression (CMA-aMCC) and inhibition (BLA-vmPFC) of …

A Brief Rational Disputation Exercise Enhances Cardiovascular, Anxiety, And Affective Recovery Following Worry-Recall, Michelle Rosalie Di Paolo

Theses and Dissertations

Rational Emotive Behavior Therapy (REBT) (Ellis, 1958), educates a client on the relationship between one’s irrational beliefs (IBs) and the dysfunctional emotional/behavioral consequences of maintaining those beliefs such as symptoms of anxiety, depression, and sleep dysfunction (Ellis, Gordan, Neenan, & Palmer, 1997), symptoms also commonly correlated with high trait perseverative cognition (PC; Verkuil, Brosschot, de Beurs, & Thayer, 2009). In addition to symptoms of anxiety and depression, high levels of PC, a construct comprised of measures of trait worry and rumination, have been linked to acute cardiovascular (CV) health concerns that overtime when left unmitigated may lead to chronic conditions …

Effects Of Dietary Preference On The Experience Of Anxiety, Depression And Acute Stress Response, Shaun Stearns

Theses and Dissertations

Research has demonstrated that high saturated fat and low carbohydrate consumption may provide physiological benefit in the treatment of major neurological disorders, though not much research has explored if these benefits extend to the experience of anxiety, depression, stress and physical symptoms. The purpose of this study was to explore the relationship between fat consumption and negative emotional/physiological states (anxiety, depression, stress and physical symptoms). This study also explored how fat consumption can alter one's response to an acute stress. Participants completed an online survey indicating their food preferences and their responses to a number of self-report scales such as …

Equity Of Social Support And Its Relationship With Depression, Anxiety, And Antiretroviral Medication Adherence Among Seroconcordant Dyads Of Hiv-Positive African Americans And Their Informal Supporters, Angela Roethel Wendorf

Theses and Dissertations

Social support may be an important resource for those coping with stigmatized chronic illnesses, such as HIV/AIDS, as social support may buffer the deleterious impact of HIV-related distress (Derlega, Winstread, Oldfield, & Barbee, 2003; Stutterheim, Bos, Pryor, Brands, Liebregts, & Schaalma, 2011; Ueno & Adams, 2001). Yet little is known about characteristics of social support among HIV-positive patients in relationships with other HIV-positive individuals and whether there is an equivalent perception and provision of support between each patient in the relationship. To examine how equity of support within the dyad may contribute to nuances in social support, mental health outcomes, …

An Examination Of The Relationship Between Levels Of Food Security And Depression, Erica K. Svojse

Theses and Dissertations

Prior research has identified a variety of common correlates between food security and depression but oftentimes the data used in these analyses are not representative of the US or do not consider multiple categorical levels of the focal variables. Using data from the 2009-2010 National Health and Nutrition Examination (NHANES), this study sought to examine the relationship between four levels of food security - full, marginal, low and very low - and depression. The findings indicate low and very low food security are significantly related to an increased risk of depression, while marginal food security is not significantly different from …

Longitudinal Associations Between Anxiety, Pain Catastrophizing, And Treatment Outcomes In Complex Pediatric Chronic Pain, Susan Tran

Theses and Dissertations

Anxiety and pain catastrophizing have been identified as factors that may predispose an individual to developing chronic pain and influence functional outcomes. The purpose of this study was to investigate the longitudinal associations of anxiety and pain catastrophizing with functional outcomes in a sample of youth seeking treatment for chronic pain. The current study aimed to expand upon recent literature by examining the relative contributions of both anxiety and pain catastrophizing to important functional outcomes (pain, functional disability, and health-related quality of life [HRQOL]) in a longitudinal design.

Participants included 725 youth (69% females, 75% Caucasian) ranging in age from …