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Combined Pharmacotherapy For The Treatment Of Traumatic Brain Injury Rehabilitation And Recovery Of Function Following Prefrontal Cortex Controlled Cortical Impact In Rats, Abby Nicole Kyser
Combined Pharmacotherapy For The Treatment Of Traumatic Brain Injury Rehabilitation And Recovery Of Function Following Prefrontal Cortex Controlled Cortical Impact In Rats, Abby Nicole Kyser
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Traumatic brain injury (TBI) is common among military personnel, resulting from bomb blasts and explosions. The secretion of pro-inflammatory cytokines following TBI has been linked to cerebral edema and neuronal loss. The use of lovastatin for TBI has been suggested to be neuroprotective by combating cytokines and inflammation. Fluoxetine has been suggested to aid in the prevention of edema during secondary injury processes, as well as having a relationship to neural plasticity. Seventy-six Long-Evans rats were randomly assigned to CCI (controlled cortical impact) or sham-operated as well as one of the following drug conditions: no treatment, vehicle, Fluoxetine only, Lovastatin …