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The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
Theses Digitization Project
The purpose of the study was to investigate the role of metabotropic glutamate receptors (mGluR) in the ontogeny of amphetamine-induced behavioral sensitization. Eleven-day-old rat pups were given five daily bilateral infusions of the mGluR antagonist, (RS)-methyl-4-carboxyphenylglycine (MCPG) followed by a systemic injection of amphetamine and locomotor activity was measured. It was hypothesized that rats receving amphetamine pretreatment and an amphetamine challenge would exhibit a significant increase in activity, indicating short-term behavioral sensitization. As predicted, repeated amphetamine administration during the pretreatment phase produced progressively enhanced locomotor activity, indicating the development of behavioral sensitization. The effect of MCPG on locomotor activity appears …
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Theses Digitization Project
The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.