Digital Commons Network^™

The Motivational Role Of Feedback On Working Memory, Danielle Wilson

Theses and Dissertations

Previous research has shown that motivation plays a vital role in what we remember. Motivation can be either extrinsic (e.g., a reward for doing well) or intrinsic (e.g., wanting to do well). Here we test if intrinsic motivation improves Working Memory (WM) performance. In an online study, undergraduate students (N=358, 334 after excluding participants that did not complete at least 25% of the survey) completed reverse letter span tasks, recalling 42 sets of 4-9 letters that were shown for one second in reverse order. We manipulate intrinsic motivation via feedback. Participants were randomly assigned to feedback (FB) and no-feedback (NFB) …

An Examination Of The Relationship Between Validity And Memory Measures In Retired Nfl Players, Huda Abu-Suwa

Theses and Dissertations

Neuropsychologists have increasingly become involved in assessing sports-related concussions; however, an important concern is the validity of the evaluations. This study examined the relationship between Performance Validity Tests (PVTs) and memory measures in a comprehensive standardized battery administered to retired NFL players, with the purpose of exploring how predictive PVTs are for memory performance in this population. Hierarchical multiple regression analyses were used to evaluate the relationship between four PVTs (TOMM, MSVT, RDS, and Word Choice) and six memory tasks (WMS-IV LM I and LM II, VPA I and VPA II, VR I and VR II). A regression analysis was …

Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer

Theses and Dissertations

The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …

Attention Capture By Episodic Long-Term Memories: Evidence From Eye Movement Data, Allison Eleanor Nickel

Theses and Dissertations

Successfully navigating the world on a moment-to-moment basis requires the interaction of multiple cognitive processes. Therefore, studies that examine when and how these fundamental processes interact can provide important insights into how we behave. Many studies indicate that long-term memory can facilitate search for a target object (e.g., contextual cueing), however, the ways in which long-term memory might capture attention and disrupt goal-directed behavior have not been well studied. In five experiments, questions about whether encoded objects might capture attention, even when they are task-irrelevant, were addressed. Each experiment began with an encoding phase, where participants were instructed to commit …

Adult And Juvenile Rats Differentially Express Mpfc Glua2 Following Traumatic Memory Retrieval, Edgar Rodriguez

Theses and Dissertations

To advance our understanding of how traumatic memories are modulated between adults and juveniles, we characterize the AMPAr subunits, GluA1, GluA2, GluA3 in the mPFC of rodents following traumatic memory retrieval.

GluA2 was differentially expressed in adults but not juveniles rats. There were no changes in GluA1 or GluA3 expression

The Influence Of Proximal Processes In Recruitment And Participation Of Monolingual Spanish-Speaking Latinos/As Living With Hiv In Neuropsychological Research In Milwaukee: An Ecological Theory Analysis From A Chicano Cultural Perspective., Enrique Ignacio Gracian

Theses and Dissertations

The goal of the original study was to examine the relationships among neuropsychological measures, laboratory measures of medication management ability, self-report and pharmacy refill records, and biometric information in monolingual Spanish-speaking Latinos/as living with HIV. The researcher experienced difficulties with recruitment and collecting valid and complete data from patients who enrolled in the study. After a one-year recruitment period and with the support of the dissertation committee and advisor, the researcher changed the focus of the dissertation to examine the data that were collected using a case study framework (Berk, 2000; Bronfenbrenner, 1977, 1979). The researcher used Bronfenbrenner Ecological Systems …

An Analysis And Comparison Of Wms-Iii And Wms-Iv Verbal Paired Associates: Practical Implications For Neuropsychologists, Anthony Paul Andrews

Theses and Dissertations

The current study examined the performance of clinical outpatients on the Verbal Paired Associates (VPA) subtest from current and prior versions of the Wechsler Memory Scale (WMS). It was predicted that VPA from the WMS-III (VPA3) would be similar in agreement to the WMS-IV (VPA4) and that VPA4 would show a stronger relationship than VPA3 with intellectual abilities, sustained attention, and executive function abilities as assessed by the WAIS-IV; CPT-2; and the TMT, Category Test, and Stroop, respectively. Thirty-six adults were administered both the WMS-III and the WMS-IV, along with the other measures as part of a larger neuropsychological battery. …

Parent Reported Executive Functioning Does Not Predict Memory Dysfunction In Pediatric Epilepsy And Attention-Deficit/Hyperactivity Disorder, Nicole J. Norheim

Theses and Dissertations

Objective: Epilepsy and Attention-Deficit/Hyperactivity Disorder (ADHD) children are vulnerable to executive functioning and memory difficulties. The interaction between EF and memory is important to consider as EF impairments may put children at risk for experiencing memory difficulties which can impact their academic performance and quality of life. However, the evidence for the impact of EF on memory is very limited with only two studies to date focusing on this association (Rzezak et al., 2012; Sepeta et al., 2017). This was the first study to research the impact of executive dysfunction on memory in the pediatric epilepsy and ADHD population. Method: …

Neural Correlates Of Memory Decisions Made In The Face Of Conflict, Elaine Mahoney

Theses and Dissertations

We’ve all experienced moments where, for some reason or another, we don’t want to reveal to others what we truly know. The current experiment investigated questions about the behavioral and neural correlates of these types of memory decisions made in the face of a conflicting goal. Participants in this experiment studied several scene-face pairs and were tested with three-face displays preceded by studied scene cues. They were instructed to indicate whether the three-face display contained the matching associate or not. Critically, half of the participants were instructed to simulate feigned memory impairment (i.e. simulators), while the remainder were instructed to …

An Analysis Of Innovate Training With Bottlenose Dolphins (Tursiops Truncatus), Raymond John Van Steyn

Theses and Dissertations

The National Aquarium in Baltimore, Maryland conducted a training program in 2014 to develop a gestural command for their dolphins called “innovate”. This training paradigm was developed to resemble the seminal research by Pryor, Haag and O’Reilly (1969), as well as more recent efforts of Braslau-Schneck (1993) and Kuczaj and Eskelinen (2014) of training dolphins to offer “creative” behaviors not developed through conventional methods of behavioral modification, such as shaping. The goal of the present study was to observe records taken during the National Aquarium’s training procedure as well as data collected ~3 years after said training in order to …

Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins

Theses and Dissertations

The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …

Intention To Deceive Alters Access To Semantic Memory, James Nye

Theses and Dissertations

I conceptualize a theory of deception within the perspective of discourse and pragmatics while choosing to examine the decision to engage in deception within the perspective of cognitive psychology. Currently, cognitive perspectives of deception have emphasized that inhibitory control of one’s motor processes are vital because in order to respond deceptively, one must prevent honest behavior from leaking into one’s actions. Although indirect evidence for inhibition is heavily linked with deception, current empirical data connecting motoric control with deceptive responses has been difficult to observe. I propose a theoretical perspective that shifts the role of inhibitory control in deception away …

The Mechanisms Underlying Cocaine-Induced Overexpression Of Basic Fibroblast Growth Factor (Bfgf, Fgf2), An Effect Reversed By Extinction, Madalyn Hafenbreidel

Theses and Dissertations

Drug addiction is characterized by compulsive drug use and chronic relapse despite negative consequences. Drug-induced structural and functional changes in the brain are thought to underlie these characteristics. One mechanism that may mediate these characteristics are growth factors, such as basic fibroblast growth factor (bFGF or FGF2), as they are necessary for cellular growth, survival, differentiation, and have roles in memory, mood, and anxiety disorders. bFGF mRNA and protein expression is increased following stimulant administration and is necessary for stimulant-induced changes in dendrites and behavioral sensitization. Moreover, addiction is maintained by cues associated with the drug, as they can can …

Sex Differences In Cognitive Decline In Mild Cognitive Impairment And Alzheimer's Disease, Juliann Thompson

Theses and Dissertations

Alzheimer's disease (AD) is the most common form of dementia and results in progressive cognitive decline, particularly in regards to memory (National Institute on Aging, 2012). Prior research has shown sex differences in brain-atrophy rates of AD patients, with women experiencing a higher rate of progression in volume reduction (Skup et al., 2011). This suggests that there may also be differences in cognitive functioning between sexes, particularly in the rate of cognitive decline with a more rapid disease progression for dementing females compared to dementing males. The current study monitored memory function longitudinally in approximately 200 total participants, 100 with …

Eye Movement Effects In Simulated Object Recognition Memory Impairment, Dmitriy Kazakov

Theses and Dissertations

Malingering is the purposeful fabrication of symptoms for secondary gain. Memory problems are the most reported symptom, and object recognition tests are often used in clinical settings to evaluate these claims. Past research has shown that eye movements can indirectly index memory, in that greater viewing is directed at studied stimuli 500-750 ms after display onset. The present study evaluated eye movements as a potential method of detecting feigned memory impairment. Forty-eight participants, half simulators, studied standardized images and took a memory test. Several levels of analysis were used to detect broad trends and brief effects. Simulators performed significantly worse …

The Influence Of Test Anxiety On Memory, James J. Malloy

Theses and Dissertations

The purpose of this study was to investigate the relationship between test anxiety and memory among a college population (N = 42). Specifically, the goal was to ascertain whether text anxiety had a measurable effect on memory, which was represented by scores on the Nelson-Denny reading comprehension subtest. Participants were divided into a stressed group (N = 22) and a non-stressed group (N = 20) in order to compare scores from test-takers with anxiety to those who do not. It was hypothesized that (a) test anxiety would have a significant impact on test results, (b) the non-stressed group would score …

Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis

Theses and Dissertations

The consolidation of fear memories is known to depend on a number of critical cellular processes including de novo protein synthesis and 26S proteasome-dependent protein degradation following auditory fear conditioning (Jarome et al., 2011; Kwapis et al., 2011). Early work has suggested that protein degradation, mediated by the ubiquitin proteasome system (UPS), may regulate the requirement for de novo protein synthesis during memory consolidation (Jarome & Helmstetter, 2014). However, the precise way in which the UPS is able to regulate mechanisms of protein synthesis remain unclear. In the present set of experiments, we investigated the role of the protein phosphatase …

Exploration Of The Wechsler Memory Scale Fourth Edition And Measures Of Executive Function Combined Components Model, Isaac Tourgeman

Theses and Dissertations

While memory is the faculty that affords us learning, adaptation and development, it is our executive function that oversees, manages and organizes these abilities. Still, there is limited research on the interaction between memory and executive function. The present study investigated this relationship through Principal Components Analysis. Performances on accepted measures of memory and executive function were evaluated in an adult clinical sample. Components were retained using three criteria: a predetermined four-component structure, eigenvalues exceeding a value of one, and parallel analysis. Results demonstrated that a four-component model most accurately represented the data. Analyses also revealed that measures of immediate …

Age Related Decline In Memory: Examining The Mediation Effect Of Processing, Executive Functioning And Intelligence In Normal Adults, Jada J. Stewart

Theses and Dissertations

Multiple mediation analyses that collectively examine the prominent theories of cognitive aging (i.e., Common Cause, Processing, and Executive Decline Hypotheses) along with other cognitive domains that are sensitive to aging are rare. Moreover, having identified that cognition begins to decline as early as 30 years old, few studies have examined the mechanisms that underlie memory change among younger aging individuals. As a result, it is unclear whether relevant mediating variables have been excluded from early research on age-related memory decline, or to what extent rehabilitative strategies are applicable as early interventions for maintaining cognitive functioning into late life.

The present …

Influence Of Seductive Details, Belief-Congruence, And Repeated Testing On Memory For Controversial Information, Daniel Adam Nuccio

Theses and Dissertations

People often encounter conflicting information on a wide array of topics. How they evaluate this information in relation to their current beliefs, and the effects of other influences, such as the weight given to superficial aspects of the information (e.g. pictures, anecdotes, or jargon that are at most minimally related to an author's argument), has been of interest to researchers for many years. One component of their processing

and evaluation of this information is their memory for the information. This study set out to examine the following questions: (1) Is belief-congruent in

formation remembered better or worse than belief incongruent …

Memory Retrieval Is Maintained By Intrinsic And Synaptic Plasticity In Prelimbic Cortex, James Otis

Theses and Dissertations

Abnormally strong memories underlie common disorders including addiction and post-traumatic stress disorder (PTSD). Memory disruption would therefore be beneficial for treatment of these disorders. Evidence reveals that cocaine conditioned place preference (CPP) memories are susceptible to long-lasting disruption during memory retrieval. For example, inhibition of β-adrenergic receptor (β-AR) activity within the prelimbic medial prefrontal cortex (PL-mPFC) prevents cocaine CPP memory retrieval, and this retrieval impairment is both long-lasting and prevents subsequent reinstatement of the CPP. Despite this, whether PL-mPFC β-AR activity is a fundamental mechanism required to maintain retrieval of other memories is unclear. Furthermore, how PL-mPFC β-AR activity maintains …

Is Contextual Cue Learning Flexible? An Eye-Movement Study Of The Contextual Cueing Task, Youcai Yang

Theses and Dissertations

Visual searching can be facilitated without awareness when the target is repeatedly presented in an invariant context in tasks such as contextual cueing (Chun & Jiang 1998). A behavioral cost (increased reaction time) was observed when the target was moved to a new location but no such cost was observed when the target returned to the initial location. The lack of cost for return suggests two possible explanations: One is that the learning can update the initial learning to acquire both target locations, which suggests the implicit learning is flexible. The other is that the contextual cue leaning cannot update …

The Effects Of Focality Of Processing And Delay On Event-Based Prospective Memory, Samantha Nicole Petrella

Theses and Dissertations

The current experiment proposes an examination of the effects of focality of processing and delays on event-based prospective memory tasks. Several perspectives regarding the process of remembering to perform an intended action in the future have been proposed by researchers in this area. Smith (2007) proposed the Preparatory Attentional and Memory (PAM) process theory regarding PM. According to the PAM theory, the retrieval of a prospective memory continuously requires resource-demanding preparatory attentional processes, or effortful and deliberate focus. Further, it suggests that successful PM retrieval is never automatic and that attention to the PM task interferes with and compromises ongoing …

The Effect Of Sleep-Dependent Consolidation On Pattern Separation And Pattern Completion In Delayed Retrieval, Jesse Ray James

Theses and Dissertations

While people sleep, the brain replays the same neural firings that resulted from waking activities that day. This results in greater memory strength following a sleeping delay than a waking delay. The current project built upon this fact in a series of three experiments. Experiment 1. Although previous research has demonstrated a benefit of sleep to memory strength, the literature has not established the impact of sleep on memory specificity. Computational models of medial temporal lobe function posit that discrimination and generalization across similar memories are accomplished through processes known as pattern separation and pattern completion, respectively. To discover whether …

Context And Target Search Reversal: Implicit Flexibility And Rapid Adaptation Of Relational Memories Using Visual Search, Ryan Hanson

Theses and Dissertations

Repeated perceptual exposure leads to increased accuracy and decreased response latency - referred to as perceptual facilitation or priming - and generally occurs in the absence of conscious memory experience. One example of a priming task which depends upon contextual relations is termed contextual cuing. It has long been held that context-dependent relations can only be acquired with deliberative or explicit processes. While context learning has historically been attributed to declarative memory, the existence of implicit context learning tasks may be better explained as an implicit relational learning process. Although implicit memories have long been characterized as relatively rigid, such …

The Role Of A Camkii/Pka-Protein Degradation-Glur2 Pathway In The Control Of Memory Updating Following Retrieval, Timothy Jarome

Theses and Dissertations

Reconsolidation is thought to be a process whereby consolidated memories can be modified following retrieval. However, very little is known about the molecular mechanisms that regulate this reconsolidation process. In the present series of experiments we tested if memories "destabilize" or become labile following retrieval through a specific signaling pathway. We found that retrieval of a contextual fear memory differentially increased proteasome activity in the amygdala and hippocampus and resulted in unique changes in AMPA receptor subunit expression in these brain regions. These changes were dependent on CaMKII activity, which was required for increases in Rpt6-S120 phosphorylation, proteasome activity and …

The Longitudinal Stability Of Memory In Males With Autism Spectrum Disorder, Alexander J. Cramond

Theses and Dissertations

Previous research has demonstrated mixed evidence on impaired memory functioning in autism spectrum disorder (ASD), with the only consensus that there appears to be much heterogeneity. In addition, no research to date has examined the stability of memory in ASD. This study examined the stability of memory function in ASD compared to typically developing age-matched controls. Participants were administered the Test of Memory and Learning (TOMAL) twice, three years apart, in an established longitudinal NIH-supported investigation of ASD. Based on available research contrasting memory development in healthy individuals versus those with ASD, it was hypothesized that memory performance in the …

The Neural Correlates Of Retrospective Memory Monitoring: Convergent Findings From Erp And Fmri, Jeremy Clark Roper

Theses and Dissertations

Monitoring the accuracy of memory is an automatic but essential process of memory encoding and retrieval. Retrospective memory confidence judgments are making effective and efficient decisions based on one's memories. The neural processes involved in retrospective confidence ratings were investigated with EEG and fMRI using a recognition memory task designed such that participants also rated their confidence in their memory response. Correct trials (hits and correct rejections) were examined for differences related to the participants' level of confidence in their response. There were significant differences in electrophysiological activity (in the FN400 and the late parietal component) associated with confidence rating, …

The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson

Theses and Dissertations

There is a growing consensus, based on several converging lines of evidence, which suggests schizophrenia is the product of a developmental insult occurring in the late 2 nd or early 3 rd trimester. Additionally, it has been observed that adults who abuse the noncompetitive NMDA antagonist PCP present with symptoms that mimic schizophrenia, such as hallucinations, formal thought disorder, delusions, unstable or flattened affect, social withdrawal, and impaired cognition. Thus, several labs have attempted to use early postnatal PCP administration in rodents as a drug model of schizophrenia. The current study investigated the cognitive effects of early postnatal PCP administration …

Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting

Theses and Dissertations

Memory impairment is common following traumatic brain injury (TBI). In recent years, researchers have demonstrated that the processes underlying memory formation (working memory, encoding, consolidation, and retrieval) are interrelated but dissociable events.The following study was designed to determine how these processes contribute to memory impairment following experimental TBI in the rat. Experiment 1 indicated thatTBI induces severe working memory deficits in a delayed non-matching-to-place task.Although all animals displayed intact acquisition, only injured animals displayed poor performance as the delay between the sample and choice phases was increased.Experiment 2 was designed to determine if TBI produces a transient period of posttraumatic …