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The Effects Of Transdermal Nicotine On Tobacco/Nicotine Withdrawal And Concurrently Administered Cigarettes In Women And Men, Betha A. Kleykamp
The Effects Of Transdermal Nicotine On Tobacco/Nicotine Withdrawal And Concurrently Administered Cigarettes In Women And Men, Betha A. Kleykamp
Theses and Dissertations
Transdermal nicotine (TN) is a smoking cessation pharmacotherapy thought to work by suppressing tobacco/nicotine withdrawal and reducing the effect of a concurrently smoked tobacco cigarette. Clinical trials suggest that TN may be less efficacious for women. This study explored the possibility of gender differences in response to transdermal nicotine in 54 women and 70 men. Participants completed four within-subject, double-blind, randomized sessions corresponding to 0, 7, 14, and 21 mg TN and 4-hrs after TN application smoked an own-brand cigarette. Prior to session onset participants completed ≥ 8 hours of verified tobacco cigarette abstinence (i.e., expired air carbon monoxide levels …
Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting
Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting
Theses and Dissertations
Memory impairment is common following traumatic brain injury (TBI). In recent years, researchers have demonstrated that the processes underlying memory formation (working memory, encoding, consolidation, and retrieval) are interrelated but dissociable events.The following study was designed to determine how these processes contribute to memory impairment following experimental TBI in the rat. Experiment 1 indicated thatTBI induces severe working memory deficits in a delayed non-matching-to-place task.Although all animals displayed intact acquisition, only injured animals displayed poor performance as the delay between the sample and choice phases was increased.Experiment 2 was designed to determine if TBI produces a transient period of posttraumatic …