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Top-Down Modulation By Medial Prefrontal Cortex Of Basal Forebrain Activation Of Auditory Cortex During Learning, Candice Monique Chavez
Top-Down Modulation By Medial Prefrontal Cortex Of Basal Forebrain Activation Of Auditory Cortex During Learning, Candice Monique Chavez
Theses Digitization Project
The experiment tested the hypothesis that the acetylcholine (ACh) release in the rat auditory cortex is greater in rats undergoing auditory classical conditioning compared to rats in a truly random control paradigm where no associative learning takes place and that this is mediated by prefrontal afferent projections influencing the nucleus basalis magnocellularis (NBM), which in turn modulates ACh release in neocortex. Rats with bilateral ibotenic acid lesions of medial prefrontal and agranular insular cortices were tested in an auditory classical conditioning task while ACh was collected from the primary auditory cortex. It was hypothesized that lesions of these prefrontal areas …