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Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh
Electronic Thesis and Dissertation Repository
Exposure to stressful events during early development has consistently been shown to produce long lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may increase vulnerability to mood and anxiety disorders. Recently reported genetic association studies indicate that these disorders may be influenced, in part, by gene-environment interactions (GxE) involving polymorphisms within the corticotrophin-releasing hormone and monoaminergic system genes. However, little is known about how genetic variants and life stress work to shape children’s neuroendocrine reactivity and emerging symptoms. Therefore, the aim of this thesis is to examine main effects of candidate genes and GxE on the neuroendocrine stress response and …
Childhood Abuse And Neglect: A Profile Of Associated Risk Factors For Non-Suicidal Self-Injury, Jennifer P. Gomez
Childhood Abuse And Neglect: A Profile Of Associated Risk Factors For Non-Suicidal Self-Injury, Jennifer P. Gomez
Electronic Thesis and Dissertation Repository
Non-suicidal self-injury (NSSI) is the intentional destruction of body tissue without suicidal intent and for purposes not socially sanctioned. Approximately 14 to 17% of nonclinical adolescent populationss and over 40% of clinical adolescent populations use NSSI to cope. NSSI is consistently related to childhood maltreatment and the objective of this study was to examine differences between maltreated individuals who do and do not self-injure. Groups were compared on risk factors of childhood maltreatment and self-injury with the intent of creating a risk profile for NSSI. Participants who had experienced abuse/neglect scored higher on depression than a contrast group, regardless of …