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Mechanisms Of Tolerance To The Effects Of Clozapine And Pimozide On A Multiple Fixed Interval 60-Second Fixed Ratio-30 Food Reinforcement Schedule In Rats, Heidi Freese Villanueva
Mechanisms Of Tolerance To The Effects Of Clozapine And Pimozide On A Multiple Fixed Interval 60-Second Fixed Ratio-30 Food Reinforcement Schedule In Rats, Heidi Freese Villanueva
Theses and Dissertations
This study examined the behavioral and biochemical effects of two neuroleptic drugs. Clozapine (10 mg/kg), an atypical neuroleptic, and pimozide (1 mg/kg), a typical neuroleptic, were administered acutely, chronically (10 days), or in a behavioral tolerance paradigm (9 days of post-session administration followed by 10 days of presession administration) in order to assess the mechanisms of tolerance. Behavioral Effects were measured on a multiple FI 60-second FR-30 operant response schedule; HPLC was used to measure the biochemical effects of clozapine in the blood plasma, frontal cortex and striatum.
Presession administration of clozapine and pimozide both produced initial disruptions of response …
Sociometric Categorization Of Children: An Empirically Based Method, Robert S. Falk
Sociometric Categorization Of Children: An Empirically Based Method, Robert S. Falk
Theses and Dissertations
The use of sociometric assessment as a method for investigating the social competence of children and the prediction of future adjustment difficulties was reviewed. Recent methods used to form up to five sociometric groups (Popular, Average, Rejected, Neglected, and Controversial) were surveyed.
Various combinations of raw scores, standard deviation units, standardized scores, and binomial probability scores have been used in classification procedures. lnclusion/exclusion criteria, or cutoff scores, have been based on arbitrary statistical decisions regarding the ”extremeness" of children’s statements (positive and negative nominations) regarding their peers. These aspects of sociometric categorization result in limitations on the validity and generalizability …