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Effect Of D-Amphetamine, Guanethidine, Disulfiram, And Stress On Gastric Ulceration In The Rat, Thomas M. Beall

Theses and Dissertations

Albino rats were injected with various doses of d-amphetamine (.02 mg/kg- 9 mg/kg) and subjected to 4 hours restraint in a cold (+5 degrees C) environment. Differential effects on ulceration were observed as a function ot the d-amphetamine dose level. Pretreatment with a .50 mg/kg injection of d-amphetamine significantly inhibited ulceration over that of saline injected, control animals, while a 9 mg/kg dose injection of the drug significantly facilitated it. Such results were explained in terms of a model interaction between sympathetic and parasympathetic nervous system activity, and the effect that such activity has on gastric conditions conducive to ulceration. …