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Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis
Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis
Undergraduate Honors Theses
Opioid misuse has been identified to be related to problematic release of dopamine in the brain that is otherwise satiated by other alternative rewards. As mediated by patterns of positive and negative reinforcement, prolonged opioid use may transition into misuse and development of opioid use disorder. In human populations, men and women differ in their acquisition of drug use and escalation to drug misuse. Women quickly surpass their male counterparts in their transition from use to misuse in what is coined the telescoping effect. In this four core genotype model of oral oxycodone self administration, males were hypothesized to consume …
Does Nicotine Alter What Is Learned About Non-Drug Incentives?, Tarra L. Baker
Does Nicotine Alter What Is Learned About Non-Drug Incentives?, Tarra L. Baker
Undergraduate Honors Theses
Nicotine is one of the most addictive drugs known to man, yet it has limited reinforcing effects in humans and non-human animals when it is not self-administered in tobacco products. One hypothesis for these paradoxical effects of nicotine is that the effects of the drug in the brain alter acquisition of incentive learning. The hypothesis for this study is that nicotine will increase the value of cues paired with a reward. To test this hypothesis, 26 Sprague Dawley Male rats were randomly assigned to one of three groups Pre-NIC (the critical experimental group), Post-NIC and SAL. Each group received a …