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Discriminative Stimulus Effects Of 3,4-Methylenedioxypyrovalerone And 4-Methylmethcathinone, Michael D. Berquist
Discriminative Stimulus Effects Of 3,4-Methylenedioxypyrovalerone And 4-Methylmethcathinone, Michael D. Berquist
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Recent escalation in the popularity of recreational synthetic cathinone (“bath salts”) use has prompted numerous scientific investigations of the neurochemical and behavioral effects of 3,4-methylenedioxypyrovalerone (MDPV) and 4-methylmethcathinone (4-MMC), two of the more common chemical constituents of these illicit “bath salts”. Previous neurochemical and electrophysiological studies have revealed that MDPV functions as a blocker, and 4-MMC as a substrate, at monoamine transporters, and both produce transient increases in extracellular monoamines. In addition, previous research has demonstrated that MDPV and 4-MMC support self-administration in nonhuman experimental subjects, and their rewarding effects are observed when paired with contextual cues in nonhuman models …