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Sex Differences In Serotonergic And Dopaminergic Mediation Of Lsd Discrimination In Rats, Keli A. Herr
Sex Differences In Serotonergic And Dopaminergic Mediation Of Lsd Discrimination In Rats, Keli A. Herr
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After decades of opposition, a resurgence of interest in the psychotherapeutic potential of LSD is gaining acceptance in the medical community. Future acceptance of LSD as a psychotherapeutic adjuvant may be predicated on knowledge about its neural mechanisms of action. Preclinical drug discrimination assay offers an invaluable model to determine the neural mechanisms underlying LSD’s interoceptive stimulus effects. Unfortunately, current preclinical literature on LSD discrimination is based on results obtained exclusively in male subjects. The present study represents the first known preclinical assessment of possible sex differences in the discriminative stimulus effects of LSD.
Adult female (n=8) and male (n=8) …