Digital Commons Network^™

Resurgence Of Cocaine-Seeking In Rats Following Long Access And Punishment, Rusty W. Nall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Strategies that provide access to alternative non-drug rewards are among the most effective at reducing substance use in individuals with substance use disorders, but relapse often occurs when alternative rewards are removed. Relapse induced by the loss of alternative rewards is called resurgence, and represents a challenge to otherwise effective strategies for reducing drug use. An animal model has been useful for studying resurgence, but the extant model has two limitations. First, humans usually refer to the negative consequences of drug use as the reason they stop taking drugs, but the extant model uses drug unavailability to reduce drug seeking. …