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Reproductive Experience And Aging : Possible Neuroprotective Effects Of Motherhood, Jessica Dawn Gatewood

Master's Theses

Hormonal fluctuations associated with pregnancy and post partum periods create significant changes in the brain and behavior in female rats. Animals were tested in a land version of the Morris Water maze for three days at 6, 12, 18 and 24 months. At the ages of 12, 18, and 24 months animals were also tested in the same maze using a reversal task. At the conclusion of the study brains were analyzed for Amyloid Precursor Protein (APP) to determine the amount of neurodegeneration among the groups. Multiparous animals showed significantly superior performance , followed by primiparous animals, and nulliparous animals …