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Devices And Methods For Electro-Physical Transport Of Dna Across Cell Membranes, Quentin Theodore Aten
Devices And Methods For Electro-Physical Transport Of Dna Across Cell Membranes, Quentin Theodore Aten
Theses and Dissertations
A novel method for charged macromolecule delivery, called nanoinjection, has been developed at Brigham Young University. Nanoinjection combines micro-fabrication technology, mechanism design, and nano-scale electrical phenomenon to transport exogenous DNA across cell membranes on a nano-featured lance. DNA is electrically accumulated on the lance, precision movements of microelectromechanical systems (MEMS) physically insert the lance into cell, and DNA is electrically released from the lance into the cell. Penetration into the cell is achieved through a two-phase, self-reconfiguring metamorphic mechanism. The surface-micromachined, metamorphic nanoinjector mechanism elevates the lance above the fabrication substrate, then translates in-plane at a constant height as the …
Modeling, Design, And Testing Of An Underwater Microactuation System Using A Standard Mems Foundry Process, Gregory L. Holst
Modeling, Design, And Testing Of An Underwater Microactuation System Using A Standard Mems Foundry Process, Gregory L. Holst
Theses and Dissertations
This work presents the modeling, design, and testing of an underwater microactuation system. It is composed of several thermomechanical in-plane microactuators (TIM) integrated with a ratchet system to provide long displacements and high forces to underwater microelectromechanical systems (MEMS). It is capable of actuating a 200µN load 110µm. It is a two-layer silicon MEMS device fabricated with a MEMS fabrication process, PolyMUMPS. This work also shows the development of an elliptic integral model to analyze the compliant fixed-guided beams in the TIM and gives new insight into the buckling behavior, reaction forces, and displacement of the beams. The derivation, verification, …
High Frequency Thermally Actuated Single Crystalline Silicon Micromechanical Resonators With Piezoresistive Readout, Amir Rahafrooz
High Frequency Thermally Actuated Single Crystalline Silicon Micromechanical Resonators With Piezoresistive Readout, Amir Rahafrooz
Electronic Theses and Dissertations
Over the past decades there has been a great deal of research on developing high frequency micromechanical resonators. As the two most common and conventional MEMS resonators, piezoelectric and electrostatic resonators have been at the center of attention despite having some drawbacks. Piezoelectric resonators provide low impedances that make them compatible with other low impedance electronic components, however they have low quality factors and complicated fabrication processes. In case of electrostatic resonators, they have higher quality factors but the need for smaller transductions gaps complicates their fabrication process and causes squeezed film damping in Air. In addition, the operation of …
Label-Free Biochemical Recognition Using Mems Resonators For Microarray Technology, Babak Tousifar
Label-Free Biochemical Recognition Using Mems Resonators For Microarray Technology, Babak Tousifar
Electronic Theses and Dissertations
Highly sensitive biosensors capable of detecting and characterizing smallest quantities of cellular and molecular targets are needed in pharmaceutical and medical diagnostics industries. In this work, the importance of biological target recognition specifically proteins through microarray technologies has been discussed and the most successful tools and techniques have been studied. Moreover, a thermally actuated Micro Electro-Mechanical Systems (MEMS) resonator has been demonstrated and fabricated in this work as an accurate, reliable and low cost biotechnology tool. As a proof of concept, amine to epoxide coupling of octadecylamine to functionalized silicon dioxide surface have been shown through resonator frequency monitoring. The …
Small Footprint High Flow Rate Microdevice For Rare Target Cell Capture, Taehyun Park
Small Footprint High Flow Rate Microdevice For Rare Target Cell Capture, Taehyun Park
LSU Doctoral Dissertations
A novel high flow rate cell capture design was introduced to overcome the limitations of the current technologies or methods for rare target cell capture. Even though the rare target cell capture using BioMEMS technology has great potential for cancer diagnosis, previous rare cell capture research could not overcome the limitations of low flow rate or low recovery rate. Rare cell research requires precise sample preparation for accurate results. A new method of preparation for a single or a precise number of target cell was introduced. Current sample preparation methods which are not suitable for rare cell research, such as …