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Modeling And Testing Of Dna Motion For Nanoinjection, Regis Agenor David
Modeling And Testing Of Dna Motion For Nanoinjection, Regis Agenor David
Theses and Dissertations
A new technique, called nanoinjection, is being developed to insert foreign DNA into a living cell. Such DNA transfection is commonly used to create transgenic organisms vital to the study of genetics, immunology, and many other biological sciences. In nanoinjection, DNA, which has a net negative charge, is electrically attracted to a micromachined lance. The lance then pierces the cell membranes, and the voltage on the lance is reversed, repelling the DNA into the cell. It is shown that DNA motion is strongly correlated to ion transport through a process called electrophoresis. Gel electrophoresis is used to move DNA using …
Continuous Electrowetting Actuation Utilizing Current Rectification Properties Of Valve Metal Films, Corey M. Lynch
Continuous Electrowetting Actuation Utilizing Current Rectification Properties Of Valve Metal Films, Corey M. Lynch
USF Tampa Graduate Theses and Dissertations
Electrowetting on dielectric (EWOD) is a technique for reducing the apparent contact angle of a fluid droplet, which has many promising applications in the fields of optics, digital displays, and lab-on-a-chip research. In this thesis, a design is presented for a novel single circuit device for achieving continuous droplet motion, by using the current-rectifying properties of valve metals to create diode-like behavior. This contrasts with existing designs, which require an array of individual electrodes to achieve motion in discrete steps. We are able to demonstrate continuous droplet motion across a 28mm-long test strip with an applied voltage of 303 V …