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Quantification Of Papillary Muscle Motion And Mitral Regurgitation After Myocardial Infarction, Connor R. Ferguson
Quantification Of Papillary Muscle Motion And Mitral Regurgitation After Myocardial Infarction, Connor R. Ferguson
Theses and Dissertations--Mechanical Engineering
Change in papillary muscle motion as a result of left ventricular (LV) remodeling after posterolateral myocardial infarction is thought to contribute to ischemic mitral regurgitation. A finite element (FE) model of the LV was created from magnetic resonance images acquired immediately before myocardial infarction and 8 weeks later in a cohort of 12 sheep. Severity of mitral regurgitation was rated by two-dimensional echocardiography and regurgitant volume was estimated using MRI. Of the cohort, 6 animals (DC) received hydrogel injection therapy shown to limit ventricular remodeling after myocardial infarction while the control group (MI) received a similar pattern of saline injections. …