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Devices And Methods For Electro-Physical Transport Of Dna Across Cell Membranes, Quentin Theodore Aten
Devices And Methods For Electro-Physical Transport Of Dna Across Cell Membranes, Quentin Theodore Aten
Theses and Dissertations
A novel method for charged macromolecule delivery, called nanoinjection, has been developed at Brigham Young University. Nanoinjection combines micro-fabrication technology, mechanism design, and nano-scale electrical phenomenon to transport exogenous DNA across cell membranes on a nano-featured lance. DNA is electrically accumulated on the lance, precision movements of microelectromechanical systems (MEMS) physically insert the lance into cell, and DNA is electrically released from the lance into the cell. Penetration into the cell is achieved through a two-phase, self-reconfiguring metamorphic mechanism. The surface-micromachined, metamorphic nanoinjector mechanism elevates the lance above the fabrication substrate, then translates in-plane at a constant height as the …
Modeling, Design, And Testing Of An Underwater Microactuation System Using A Standard Mems Foundry Process, Gregory L. Holst
Modeling, Design, And Testing Of An Underwater Microactuation System Using A Standard Mems Foundry Process, Gregory L. Holst
Theses and Dissertations
This work presents the modeling, design, and testing of an underwater microactuation system. It is composed of several thermomechanical in-plane microactuators (TIM) integrated with a ratchet system to provide long displacements and high forces to underwater microelectromechanical systems (MEMS). It is capable of actuating a 200µN load 110µm. It is a two-layer silicon MEMS device fabricated with a MEMS fabrication process, PolyMUMPS. This work also shows the development of an elliptic integral model to analyze the compliant fixed-guided beams in the TIM and gives new insight into the buckling behavior, reaction forces, and displacement of the beams. The derivation, verification, …