Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 8 of 8
Full-Text Articles in Entire DC Network
Novel Quantitative Macro Biomolecule Analysis Based On A Micro Coulter Counter, Y Han, H. Wu, F. Liu, Gang Cheng, Jiang Zhe
Novel Quantitative Macro Biomolecule Analysis Based On A Micro Coulter Counter, Y Han, H. Wu, F. Liu, Gang Cheng, Jiang Zhe
Mechanical Engineering Faculty Research
We demonstrate quantitative biomolecule analysis using a micro coulter counter. Specific binding between antibody functionalized microparticles and target biomolecule cause large aggregates of microparticles. The micro coulter counter was employed to measure aggregation ratio, ratio of the aggregate counts to the total particle counts. Goat anti-rabbit IgG, used as a model biomarker, were tested in this paper. The experiment results showed that the aggregation ratio increases with the increasing biomolecule concentration, and the detectable concentration range from 16 to 160 ng/ml was achieved.
Passive Continuous Particle Focusing In A Microchannel With Symmetric Sharp Corner Structures, Liang-Liang Fan, Liang Zhao, Xu-Kun He, Hand Yu, Qing-Yu Wei, Jiang Zhe
Passive Continuous Particle Focusing In A Microchannel With Symmetric Sharp Corner Structures, Liang-Liang Fan, Liang Zhao, Xu-Kun He, Hand Yu, Qing-Yu Wei, Jiang Zhe
Mechanical Engineering Faculty Research
We report a continuous passive particle focusing method using a novel microchannel with symmetric sharp corners which induce curved streamlines and large centrifugal force on particles. At appropriate flow rate, the centrifugal force generated on particles exceeds the inertial lift force; particles driven by the centrifugal force migrate toward the center of the microchannel, achieving continuous particle focus-ing. With simple structure and operation, this method can be potentially used in particle focusing and ex-traction processes in a variety of lab-on-a chip applications.
A New Microfluidic Device For Complete, Continuous Separation Of Microparticles, Liang-Liang Fan, Xu-Kun He, Yu Han, Li Du, Liang Zhao, Jiang Zhe
A New Microfluidic Device For Complete, Continuous Separation Of Microparticles, Liang-Liang Fan, Xu-Kun He, Yu Han, Li Du, Liang Zhao, Jiang Zhe
Mechanical Engineering Faculty Research
A microchannel with symmetric sharp corners is reported for particle separation, based on the inter-play between the inertial lift force and the centrifugal force induced by sharp corners. At an appropriate flow rate, the centrifugal force is larger than the inertial lift force on large particles, while the inertial lift force is dominant on small particles. Hence large particles are centrifuged to the center, while small par-ticles are focused at side streams, achieving complete particle separation. The device requires no sheath flow, avoiding the dilution of analyte sample and complex operation, and can be potentially used for many lab-on-a-chip applications.
Reinterpretation Of Velocity-Dependent Atomic Friction: Influence Of The Inherent Instrumental Noise In Friction Force Microscopes, Yalin Dong, Hongyu Gao, Ashlie Martini, Philip Egberts
Reinterpretation Of Velocity-Dependent Atomic Friction: Influence Of The Inherent Instrumental Noise In Friction Force Microscopes, Yalin Dong, Hongyu Gao, Ashlie Martini, Philip Egberts
Mechanical Engineering Faculty Research
We have applied both the master equation method and harmonic transition state theory to interpret the velocity-dependent friction behavior observed in atomic friction experiments. To understand the discrepancy between attempt frequencies measured in atomic force microscopy experiments and those estimated by theoretical models, both thermal noise and instrumental noise are introduced into the model. It is found that the experimentally observed low attempt frequency and the transition point at low velocity regimes can be interpreted in terms of the instrumental noise inherent in atomic force microscopy. In contrast to previous models, this model also predicts (1) the existence of a …
Numerical Analysis Of Cold Injury Of Skin In Cryogen Spray Cooling For Laser Dermatologic Surgery, Dong Li, Bin Chen, Wen-Juan Wu, Ya-Ling He, Lin Zhuang Xing, Guo-Xiang Wang
Numerical Analysis Of Cold Injury Of Skin In Cryogen Spray Cooling For Laser Dermatologic Surgery, Dong Li, Bin Chen, Wen-Juan Wu, Ya-Ling He, Lin Zhuang Xing, Guo-Xiang Wang
Mechanical Engineering Faculty Research
In laser dermatologic surgery, cryogen spray cooling (CSC) is used to avoid unwanted thermal damage such as scars from skin burning due to the melanin absorption of the laser beam. As the cryogen is fully atomized from the nozzle, temperature of the droplets can quickly drop below -60 oC because of evaporation. Such low temperature may lead to cold injury of skin. Therefore, spray cooling process should be accurately controlled during clinical practice to achieve sufficient protection and avoid cold injury. This study presents a numerical analysis for cold injury of skin in cryogen spray cooling for dermatologic laser surgery …
The General Public’S Weather Information-Seeking And Decision-Making Behavior During Tornado Outbreaks In The Oklahoma City Metroplex In May 2013, Chen Ling, Michelle Madison, Jessica Adams, Kevin Warren, Michael Mudd, Kim Graves Wolfinbarger, Lans Rothfusz
The General Public’S Weather Information-Seeking And Decision-Making Behavior During Tornado Outbreaks In The Oklahoma City Metroplex In May 2013, Chen Ling, Michelle Madison, Jessica Adams, Kevin Warren, Michael Mudd, Kim Graves Wolfinbarger, Lans Rothfusz
Mechanical Engineering Faculty Research
Severe weather impacts the lives of many people. Today's technology allows weather information to be distributed to the general public in many ways. However, it is not clear how people obtain information regarding severe weather, and how they make decisions based on the information. This study surveyed people in the Oklahoma City metroplex about their weather information–seeking and decision-making behaviors during the May 2013 tornado outbreaks. The preliminary results based on 124 survey responses show that people used and trusted television news most to obtain the severe weather information, followed by siren, weather radio, radio, looking at the sky, and …
Electromyogram Synergy Control Of A Dexterous Artificial Hand To Unscrew And Screw Objects, Benjamin A. Kent, Nareen Karnati, Erik D. Engeberg
Electromyogram Synergy Control Of A Dexterous Artificial Hand To Unscrew And Screw Objects, Benjamin A. Kent, Nareen Karnati, Erik D. Engeberg
Mechanical Engineering Faculty Research
Due to their limited dexterity, it is currently not possible to use a commercially available prosthetic hand to unscrew or screw objects without using elbow and shoulder movements. For these tasks, prosthetic hands function like a wrench, which is unnatural and limits their use in tight working environments. Results from timed rotational tasks with human subjects demonstrate the clinical need for increased dexterity of prosthetic hands, and a clinically viable solution to this problem is presented for an anthropomorphic artificial hand.
Active Infrared Sensing Of Impact Damage In Carbon Fibre Reinforced Polymer, Kwek Tze Tan, Liping Zhao, Shaochun Ye, Tong Kuan Chuah, Pramoda Kumari Pallathadka, Hui Ru Tan
Active Infrared Sensing Of Impact Damage In Carbon Fibre Reinforced Polymer, Kwek Tze Tan, Liping Zhao, Shaochun Ye, Tong Kuan Chuah, Pramoda Kumari Pallathadka, Hui Ru Tan
Mechanical Engineering Faculty Research
With the growing demand of carbon fibre reinforced plastic (CFRP) in aerospace, marine and automobile industries, much attention is devoted to characterizing the material strength and characteristics of failure. This paper demonstrated the feasibility to estimate the internal damage non-destructively as a result of a quantified impact applied on 16-ply fabric CFRP. On thermography images at different heating time, differences were observed between intact area and area with internal damage. The estimation of 1D extent of damage using thermographic analysis was compared with images observed with cross sectional microscopic. The results suggest that qualitative analysis using thermography shows potential to …