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An Ontology-Driven Semantic Mash-Up Of Gene And Biological Pathway Information: Application To The Domain Of Nicotine Dependence, Satya S. Sahoo, Olivier Bodenreider, Joni L. Rutter, Karen J. Skinner, Amit P. Sheth
An Ontology-Driven Semantic Mash-Up Of Gene And Biological Pathway Information: Application To The Domain Of Nicotine Dependence, Satya S. Sahoo, Olivier Bodenreider, Joni L. Rutter, Karen J. Skinner, Amit P. Sheth
Kno.e.sis Publications
Objectives: This paper illustrates how Semantic Web technologies (especially RDF, OWL, and SPARQL) can support information integration and make it easy to create semantic mashups (semantically integrated resources). In the context of understanding the genetic basis of nicotine dependence, we integrate gene and pathway information and show how three complex biological queries can be answered by the integrated knowledge base.
Methods: We use an ontology-driven approach to integrate two gene resources (Entrez Gene and HomoloGene) and three pathway resources (KEGG, Reactome and BioCyc), for five organisms, including humans. We created the Entrez Knowledge Model (EKoM), an information model in OWL …
Rdb2rdf: Incorporating Domain Semantics In Structured Data, Satya S. Sahoo
Rdb2rdf: Incorporating Domain Semantics In Structured Data, Satya S. Sahoo
Kno.e.sis Publications
No abstract provided.