Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Computational Design Of Orthogonal Ribosomes, Lon Chubiz, Christopher Rao
Computational Design Of Orthogonal Ribosomes, Lon Chubiz, Christopher Rao
Biology Department Faculty Works
Orthogonal ribosomes (o-ribosomes), also known as specialized ribosomes, are able to selectively translate mRNA not recognized by host ribosomes. As a result, they are powerful tools for investigating translational regulation and probing ribosome structure. To date, efforts directed towards engineering o-ribosomes have involved random mutagenesisbased approaches. As an alternative, we present here a computational method for rationally designing o-ribosomes in bacteria. Working under the assumption that base-pair interactions between the 16S rRNA and mRNA serve as the primary mode for ribosome binding and translational initiation, the algorithm enumerates all possible extended recognition sequences for 16S rRNA and then chooses those …
Diethyl 2-[(4-NitroPhenYl)(4-Phenyl-1,2,3-Selenadiazol-5-Yl)MethYl]Malonate, A. Marx, S. Saravanan, S. Muthusubramanian, V. Manivannan, Nigam Rath
Diethyl 2-[(4-NitroPhenYl)(4-Phenyl-1,2,3-Selenadiazol-5-Yl)MethYl]Malonate, A. Marx, S. Saravanan, S. Muthusubramanian, V. Manivannan, Nigam Rath
Chemistry & Biochemistry Faculty Works
In the title compound, C22H21N3O6Se, the heterocyclic ring makes dihedral angles of 50.03 (11) and 67.75 (11)°, respectively, with the benzene and phenyl rings. The terminal C atoms of the ester groups are disordered over two positions: the site occupancies for the C atoms are 0.62 (3)/0.38 (3) and 0.48 (3)/0.52 (3). In the crystal structure, weak intra- and intermolecular C-H...O interactions are observed.
Dioxidobis(2-Oxo-1,2-Dihydropyridin-3-Olato)Molybdenum(Vi), Manoj Trivedi, Daya Pandey, Nigam Rath
Dioxidobis(2-Oxo-1,2-Dihydropyridin-3-Olato)Molybdenum(Vi), Manoj Trivedi, Daya Pandey, Nigam Rath
Chemistry & Biochemistry Faculty Works
In the title compound, [Mo(C5H4NO2)2O2], the MoVI atom exhibits a distorted octahedral coordination geometry formed by two terminal oxo ligands and two monoanionic O,O-bidentate pyridinone ligands. The two terminal oxo ligands lie in a cis arrangement, the ketonic O atoms of the pyridinone ligands are coordinated trans to the oxo ligands and the deprotonated hydroxyl O atoms are located trans to each other. The crystal structure contains intermolecular N-H...O hydrogen bonds, C-H...O contacts and face-to-face [pi]-[pi] stacking interactions with an interplanar separation of 3.25 (1) Å.
4-(4-Chlorophenyl)-5-[1-(4-Chlorophenyl)-2-Methyl-2-Nitropropyl]-1,2,3-Selenadiazole, A. Marx, S. Saravanan, S. Muthusubramanian, V. Manivannan, Nigam Rath
4-(4-Chlorophenyl)-5-[1-(4-Chlorophenyl)-2-Methyl-2-Nitropropyl]-1,2,3-Selenadiazole, A. Marx, S. Saravanan, S. Muthusubramanian, V. Manivannan, Nigam Rath
Chemistry & Biochemistry Faculty Works
In the title compound, C18H15Cl2N3O2Se, the selenadiazole ring makes dihedral angles of 49.87 (3) and 55.70 (3)° with the two benzene rings. The dihedral angle between the two benzene rings is 11.90 (5)°. In the crystal structure, intramolecular C-H...O and C-H...Se interactions and intermolecular C-H...O, C-H...Cl and C-H...N interactions are observed.