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Microsyn: A User Friendly Tool For Detection Of Microsynteny In A Gene Family, Bin Cai, Xiaohan Yang, Gerald A. Tusken, Zong-Ming Cheng
Microsyn: A User Friendly Tool For Detection Of Microsynteny In A Gene Family, Bin Cai, Xiaohan Yang, Gerald A. Tusken, Zong-Ming Cheng
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Background
The traditional phylogeny analysis within gene family is mainly based on DNA or amino acid sequence homologies. However, these phylogenetic tree analyses are not suitable for those "non-traditional" gene families like microRNA with very short sequences. For the normal protein-coding gene families, low bootstrap values are frequently encountered in some nodes, suggesting low confidence or likely inappropriateness of placement of those members in those nodes.
Results
We introduce MicroSyn software as a means of detecting microsynteny in adjacent genomic regions surrounding genes in gene families. MicroSyn searches for conserved, flanking colinear homologous gene pairs between two genomic fragments to …