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Growth Factor-Free And Antimicrobial Elastic Nanocomposites For Bone Regeneration, Dina Mohsen Ibrahim
Growth Factor-Free And Antimicrobial Elastic Nanocomposites For Bone Regeneration, Dina Mohsen Ibrahim
Theses and Dissertations
Elastic platforms have been shown recently to be advantageous for bone tissue engineering. Specifically, PEGylated polyglycerol sebecate has recently been reported in literature as a modification for Poly glycerol sebacate (PGS). It is highly elastic with tunable mechanical properties, rendering it an interesting candidate for bone regeneration. However, it lacks the bioactive and antimicrobial properties that are essential for bone tissue engineering scaffolds. To address these issues, herein, PEGylated PGS with different PEG ratios was mixed with PCL to obtain uniform electrospun mats. Further functions were added to the structure to render it osteoinductive and antimicrobial through the addition of …
The New Penicillin?, Nikki Huynh
The New Penicillin?, Nikki Huynh
EGS Content
Clostridium difficile infects and kills 30,000-40,000 people a year in the United States. In order to target and minimize the spread of C. difficile we are screening puupehenone, a natural marine product that is excreted from some species of sponges and coral as a defense mechanism, and repurposing its role for medical use. Our research primarily focuses on determining puupehenone’s antimicrobial properties. This was determined by testing the minimum inhibitory concentration (MIC) of puupehenone as it relates to a single strain of C. difficile, and then observing whether the antimicrobial properties hold across multiple strains of the bacterium. The strain …
Ag Nanoparticles Generated Using Bio-Reduction And –Coating Cause Microbial Killing Without Cell Lysis, Gade A. Adams, Joan E. Mclean, J. Adams, D. W. Britt, Fenann Shen, A. Jacobson, Y. C. Kim
Ag Nanoparticles Generated Using Bio-Reduction And –Coating Cause Microbial Killing Without Cell Lysis, Gade A. Adams, Joan E. Mclean, J. Adams, D. W. Britt, Fenann Shen, A. Jacobson, Y. C. Kim
Civil and Environmental Engineering Faculty Publications
Cost-effective “green” methods of producing Ag nanoparticles (NPs) are being examined because of the potential of these NPs as antimicrobials. Ag NPs were generated from Ag ions using extracellular metabolites from a soil-borne Pythium species. The NPs were variable in size, but had one dimension less than 50 nm and were biocoated; aggregation and coating changed with acetone precipitation. They had dose-dependent lethal effects on a soil pseudomonad, Pseudomonas chlororaphis O6, and were about 30-fold more effective than Ag+ ions. A role of reactive oxygen species in cell death was demonstrated by use of fluorescent dyes responsive to superoxide anion …