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Novel Synthesis Of 3,4-Fused Indoles, Jeremiah Wallace Hubbard
Novel Synthesis Of 3,4-Fused Indoles, Jeremiah Wallace Hubbard
Graduate Theses, Dissertations, and Problem Reports
The goal of this project was to synthesize 3,4-fused indoles having a variety of ring sizes and a variety of functional groups. This has been accomplished by the development of a novel palladium-catalyzed route to 3,4-fused indoles. The key steps are two palladium-catalyzed reactions, an intramolecular Heck reaction followed by a reductive N-heteroannulation. Using this route, a number of 3,4-fused indoles were prepared in acceptable yields.