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Fabrication Of Layer-By-Layer Ecm/Polysaccharides/Electrospun Composite Nanofibrous Scaffolds And Hydrogels For In-Vitro Skin Cell Regeneration, Fatma Nabil El-Shishiny
Fabrication Of Layer-By-Layer Ecm/Polysaccharides/Electrospun Composite Nanofibrous Scaffolds And Hydrogels For In-Vitro Skin Cell Regeneration, Fatma Nabil El-Shishiny
Theses and Dissertations
Skin burn wounds is a crucial issue that could reduce life quality. The novel tri-layered asymmetric porous scaffold has been innovated to mimic the natural skin layers. The scaffold constitutes of upper electrospun Cs-PVA layer and lower xerogel layer that made of effective skin ECM components. Both layers were stuck together by fibrin glue. The developed scaffold resulted in promising swelling capability suitable for absorbing wound exudates, followed by constant degradable weight over time which is appropriate for burn wounds environment. SEM images revealed the presence of significant pore distribution among the electrospun and xerogel layers confirmed by BET analysis. …
Nanostructured Scaffold For Neural Tissue Regeneration, Walaa Abbas
Nanostructured Scaffold For Neural Tissue Regeneration, Walaa Abbas
Theses and Dissertations
Neural regeneration treatment after spinal cord injury (SCI) is still unsatisfactory despite the advances made in the field. One of the main challenges in neural tissue engineering is the axonal growth and directionality. Cell and molecular therapies can enhance the axonal attachment and growth. However, axons may be unsuccessful to maintain their native organization and may grow in a disorganized fashion. Nanofiber scaffolds represent a potential solution for the problem of nerve regeneration and axon extension, as they can mimic the neural tissue extra cellular matrix (ECM) and combine the advantages of the combinatorial therapy for nerve injury in SCI …