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Evolution Of Nervous System Centralization: Role Of Bmp Signaling In Neural Fate And Dorsal-Ventral Axis Specification In Capitella Teleta, Christie Joyce
Evolution Of Nervous System Centralization: Role Of Bmp Signaling In Neural Fate And Dorsal-Ventral Axis Specification In Capitella Teleta, Christie Joyce
Biology
Bone Morphogenetic Protein (BMP) signaling plays an important role in establishing the dorsal-ventral (D-V) axis across Bilateria. BMP signaling has also been implicated in neural fate specification in several bilaterians that possess centralized nervous systems. The classic examples are found in vertebrates and Drosophila melanogaster, where opposing gradients of BMP2/4/Dpp and Chordin/Sog specify the D-V axis and the nervous system arises on the Chordin/Sog side of the early embryo due to the anti-neural role of BMPs. These similarities have been used as support for the hypothesis that the bilaterian ancestor possessed a centralized nervous system and that BMP signaling delimited …