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Novel Intraocular Drug Delivery System For The Prevention Of Posterior Capsule Opacification, Brett Thomes

Bioengineering Dissertations

Posterior capsule opacification (PCO) is a major complication associated with the implantation of intraocular lens (IOLs). Evidence suggests that PCO formation is caused by abnormal lens epithelial cell (LEC) migration/proliferation. We hypothesize that pharmacologic agents must target inflammatory cells in addition to LECs to inhibit PCO formation. To successfully target both inflammatory cells and LECs, a novel intraocular drug delivery system (DDS) was developed for implantation in the lens capsular bag. Such a system permits direct delivery of anti-inflammatory and anti-proliferative drugs in the lens capsule for extended periods of time resulting in reduced PCO formation. A lubricious polyurethane coating …