Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Enhancing Gdf1 Expression With Devil’S Club (Oplopanax Horridus) Extracts In Acute Myeloid Leukemia, Vasiliki Papakotsi
Enhancing Gdf1 Expression With Devil’S Club (Oplopanax Horridus) Extracts In Acute Myeloid Leukemia, Vasiliki Papakotsi
Doctoral Dissertations
Acute myeloid leukemia (AML) is a clonal hematopoietic malignancy with highly heterogeneous molecular and clinical profiles. It is one of the deadliest blood cancers, resulting in approximately 10,000 deaths each year. Impaired hematopoiesis is one of AML’s hallmarks. This entails defective erythropoiesis and proliferation of undifferentiated myeloblasts. AML is also characterized by chemoresistance and high relapse rates. Despite significant advances in treatments, there is no cure for AML. Therefore, there is an emerging and unmet need to shift away from traditional chemotherapeutics and focus on targeted therapies with curative potential. Growth/differentiation factor 1 (GDF1) is a member of the TGFβ …