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Cannabis Consumption Patterns Explain The East-West Gradient In Canadian Neural Tube Defect Incidence: An Ecological Study [Dataset], Albert Stuart Reece, Gary Kenneth Hulse
Cannabis Consumption Patterns Explain The East-West Gradient In Canadian Neural Tube Defect Incidence: An Ecological Study [Dataset], Albert Stuart Reece, Gary Kenneth Hulse
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While a known link between prenatal cannabis exposure and anencephaly exists, the relationship of prenatal cannabis exposure with neural tube defects (NTDs) generally has not been defined. Published data from Canada Health and Statistics Canada were used to assess this relationship. Both cannabis use and NTDs were shown to follow an east-west and north-south gradient. Last year cannabis consumption was significantly associated (P < .0001; cannabis use–time interaction P < .0001). These results were confirmed when estimates of termination for anomaly were used. Canada Health population data allowed the calculation of an NTD odds ratio) of 1.27 (95% confidence interval = 1.19-1.37; P < 10−11) for high-risk provinces versus the remainder with an attributable fraction in exposed populations of 16.52% (95% confidence interval = 12.22-20.62). Data show a robust positive statistical association between cannabis consumption as both a qualitative and quantitative variable and NTDs on a background of declining NTD incidence. In the context of multiple mechanistic pathways these strong statistical findings implicate causal mechanisms.
Isolation, Characterization, And Cross-Amplification Of 20 Microsatellite Markers For The Rare Conospermum Undulatum (Proteaceae) [Dataset], Nicola Delnevo, Andrea Piotti, Eddie J. Van Etten, William D. Stock, Margaret Byrne
Isolation, Characterization, And Cross-Amplification Of 20 Microsatellite Markers For The Rare Conospermum Undulatum (Proteaceae) [Dataset], Nicola Delnevo, Andrea Piotti, Eddie J. Van Etten, William D. Stock, Margaret Byrne
Research Datasets
Premise of the study: Recent habitat fragmentation is posing a risk to the wavy-leaved smokebush, Conospermum undulatum, a rare plant species endemic to the south-western Western Australia. Microsatellites markers are required to characterize the genetic diversity and structure of the species for conservation purposes and to facilitate ecological studies. Methods and Results: Illumina MiSeq high-throughput sequencing was used to develop 20 novel microsatellite markers for C. undulatum. Polymorphism at each locus was assessed using 72 individuals from three natural populations. Nineteen markers were polymorphic, with the number of alleles per locus ranging from two to 21, and observed and expected …