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Population Genetics Of Freshwater Pearl Mussel (Margaritifera Margaritifera) In Central Massachusetts And Implications For Conservation, Stefanie Farrington
Population Genetics Of Freshwater Pearl Mussel (Margaritifera Margaritifera) In Central Massachusetts And Implications For Conservation, Stefanie Farrington
Biology
The freshwater pearl mussel Margaritifera margaritifera is an ecologically-important globally-endangered species, yet little is known about biodiversity and population genetics in North American populations. We focused our study on M. margaritifera from central and eastern Massachusetts, USA, to better understand the historical impact of damming and habitat fragmentation on local population structure and genetic diversity. In order to examine the local population genetics of M. margaritifera, we generated ~300 informative single nucleotide polymorphisms (SNPs) from 59 individuals across 6 geographic locations, using the RAD-seq approach. We also gleaned genotypes from publicly available RNA-seq data of 23 French M. margaritifera samples. …
A Functional Analysis Of Drosophila Plcgamma And The Screening For A Novel Inhibitor, Michelle K. Latino
A Functional Analysis Of Drosophila Plcgamma And The Screening For A Novel Inhibitor, Michelle K. Latino
Biology
The epidermal growth factor receptor, EGFR, pathway is a highly conserved and complicated pathway required for cell growth, proliferation, migration, and proper regulation of the pathway is required for normal development (reviewed by Fischer et al., 2003). Due to the pathways role in development, the EGFR pathway is often implicated with various diseases including cancer. The EGFR pathway is regulated by various proteins including by PLCgamma which works to regulate the pathway by promoting motility, adhesion, and differentiation (Murillo-Maldonado et al., 2011; Butchar et al., 2012; Shepard et al., 2006). Because of the role PLCgamma plays in cell proliferation, it …