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Studies On Guest/Host Complexes, Liposomal And Other Systems For Potential Chemotherapeutic Drug(S) Delivery, Sherif Ashraf Fahmy
Studies On Guest/Host Complexes, Liposomal And Other Systems For Potential Chemotherapeutic Drug(S) Delivery, Sherif Ashraf Fahmy
Theses and Dissertations
Following the discovery of cisplatin over 50 years ago, this platinum-based drug (PBD) has been a widely used and effective form of cancer therapy, primarily causing cell death by inducing DNA damage and triggering apoptosis. However, the dose limiting toxicity of cisplatin has led to the development of the newer generations' platinum-based drugs (second and third) that maintain the cytotoxicity of cisplatin but have more acceptable side-effect profiles. In addition to the creation of new analogs, tumor delivery systems such as liposome-encapsulated platinum drugs have been designed and are currently in clinical trials. In this study, we have created and …
Metal-Decorated Carbon Nanotubes For Gas Sensing Applications, Icell Sharafeldin
Metal-Decorated Carbon Nanotubes For Gas Sensing Applications, Icell Sharafeldin
Theses and Dissertations
This thesis reports on the investigation of metal-decorated carbon nanotubes-based sensor arrays with enhanced sensitivity and selectivity toward toxic gases. Ab initio first-principles methods were used to expedite the process of identifying the right materials with the highest potential compared to in-lab trial and error as well as to provide a deeper understanding of the gas adsorption mechanism. The mechanism of NO2 adsorption on Cu-, Pt- and Ti-doped single-walled carbon nanotubes (SWCNTs) was investigated. Modelling the isolated NO2 molecule indicated the formation of a band gap between the 3Ï€* HOMO and 5σ* LUMO levels, which were found to be the …