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Targeting Dusps In Glioblastomas–Wielding A Double‐Edged Sword, Sheila Abraham, Swapna Asuthkar, William Lee, Srinivasulu Chigurupat, Andrew Tsung, Kiran Kiran
Targeting Dusps In Glioblastomas–Wielding A Double‐Edged Sword, Sheila Abraham, Swapna Asuthkar, William Lee, Srinivasulu Chigurupat, Andrew Tsung, Kiran Kiran
Sheila Prabhakar Abraham
Several dual-specificity phosphatases (DUSPs) that play key roles in the direct or indirect inactivation of different MAP kinases (MAPKs) have been implicated in human cancers over the past decade. This has led to a growing interest in identifying DUSPs and their specific inhibitors for further testing and validation as therapeutic targets in human cancers. However, the lack of understanding of the complex regulatory mechanisms and cross-talks between MAPK signaling pathways, combined with the fact that DUSPs can act as a double-edged sword in cancer progression, calls for a more careful and thorough investigation. Among the various types of brain cancer, …
Improving The Selective Cancer Killing Ability Of Zno Nanoparticles Using Fe Doping, Aaron Thurber, Denise Wingett, John Rasmussen, Janet Layne, Lydia Johnson, Dmitri Tenne, Jianhui Zhang, Charles Hanna, Alex Punnoose
Improving The Selective Cancer Killing Ability Of Zno Nanoparticles Using Fe Doping, Aaron Thurber, Denise Wingett, John Rasmussen, Janet Layne, Lydia Johnson, Dmitri Tenne, Jianhui Zhang, Charles Hanna, Alex Punnoose
Lydia Johnson
This work reports a new method to improve our recent demonstration of zinc oxide (ZnO) nanoparticles (NPs) selectively killing certain human cancer cells, achieved by incorporating Fe ions into the NPs. Thoroughly characterized cationic ZnO NPs (∼6 nm) doped with Fe ions (Zn(1-x )Fe (x) O, x = 0-0.15) were used in this work, applied at a concentration of 24 μg/ml. Cytotoxicity studies using flow cytometry on Jurkat leukemic cancer cells show cell viability drops from about 43% for undoped ZnO NPs to 15% for ZnO NPs doped with 7.5% Fe. However, the trend reverses and cell viability increases with …
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Richard A. Malthaner
Background and purpose: Extended volume external beam radiation therapy (RT) following esophagectomy is controversial. This prospective study evaluates the feasibility of extended volume RT treatment in high-risk esophagectomy patients with cervical anastomosis receiving post–operative combined chemo-radiation therapy. Patients and methods: From 2001-2006, 15 patients with resected esophageal cancer were prospectively accrued to this pilot study, to evaluate the adverse effects of extended volume RT. Eligibility criteria were pathologically proven esophageal malignancy, T3-4, N0-1, disease amenable to surgical resection and esophagectomy with or without resection margin involvement. Patients with distant metastases (M1) and patients treated with previous RT were excluded. All …
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Richard A. Malthaner
Background and purpose: Extended volume external beam radiation therapy (RT) following esophagectomy is controversial. This prospective study evaluates the feasibility of extended volume RT treatment in high-risk esophagectomy patients with cervical anastomosis receiving post–operative combined chemo-radiation therapy. Patients and methods: From 2001-2006, 15 patients with resected esophageal cancer were prospectively accrued to this pilot study, to evaluate the adverse effects of extended volume RT. Eligibility criteria were pathologically proven esophageal malignancy, T3-4, N0-1, disease amenable to surgical resection and esophagectomy with or without resection margin involvement. Patients with distant metastases (M1) and patients treated with previous RT were excluded. All …
Three-Dimensional Engineered Matrix To Study Cancer Stem Cells And Tumorsphere Formation: Effect Of Matrix Modulus, Xiaoming Yang, Samaneh Sarvestani, Seyedsina Moeinzadeh, Xuezhong He, Esmaiel Jabbari
Three-Dimensional Engineered Matrix To Study Cancer Stem Cells And Tumorsphere Formation: Effect Of Matrix Modulus, Xiaoming Yang, Samaneh Sarvestani, Seyedsina Moeinzadeh, Xuezhong He, Esmaiel Jabbari
Esmaiel Jabbari
Maintenance of cancer stem cells (CSCs) is regulated by the tumor microenvironment. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment. The objective of this work was to investigate the effect of matrix modulus on tumorsphere formation by breast cancer cells and maintenance of CSCs in an inert microenvironment without the interference of other factors. In that regard, 4T1 mouse breast cancer cells were encapsulated in inert polyethylene glycol diacrylate hydrogels and the effect of matrix modulus on tumorsphere formation and expression of CSC markers was investigated. The gel …
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Nima Rahbar
This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …