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Development Of Mouse Models For The Study Of Zika Virus Pathogenesis And Antibody Response, Anna Beatriz Kawiecki
Development Of Mouse Models For The Study Of Zika Virus Pathogenesis And Antibody Response, Anna Beatriz Kawiecki
LSU Master's Theses
After the emergence of Zika virus (ZIKV) in the Americas in 2015, ZIKV infection was associated for the first time since its discovery with severe symptoms in both adults and congenital cases, including neurological, ocular, and developmental manifestations. Previous ZIKV circulation in Africa and Southeast Asia has been characterized by mild symptoms and small-scale case-counts. It is unclear whether the unprecedented size and severity of the ZIKV outbreak in the Americas are the consequence of a change in the virus, different background flaviviral immunity in the population, or a reporting issue. In addition, ZIKV has been shown to be transmitted …
Evaluation Of Broad Anti-Herpesviral Activity With Α-Hydroxytropolones, Shannon David Dehghanpir
Evaluation Of Broad Anti-Herpesviral Activity With Α-Hydroxytropolones, Shannon David Dehghanpir
LSU Master's Theses
Herpesviruses are ubiquitous in animals and cause economic losses concomitant with many diseases, including upper respiratory disease, keratitis, abortion, neonatal death, and neurologic disease. The majority of the domestic animal herpesviruses are within the subfamily Alphaherpesvirinae, along with the prototypical human herpes simplex virus 1 (HSV-1). Suppression of HSV-1 replication has been reported with α-hydroxytropolones (αHTs), which are aromatic ring compounds that have broad bioactivity due to potent chelating activity. It is postulated that αHTs inhibit enzymes within the nucleotidyltransferase superfamily (NTS), similarly structured enzymes that require divalent cations for nucleic acid cleavage activity. One potential herpesviral target includes the …
Quantitation Of Anti-Pythium Insidiosum Antibodies Before And After Immunotherapy In Healthy Dogs, Carmen Beatriz Arsuaga
Quantitation Of Anti-Pythium Insidiosum Antibodies Before And After Immunotherapy In Healthy Dogs, Carmen Beatriz Arsuaga
LSU Master's Theses
Pythium insidiosum is an aquatic oomycete that causes invasive, progressive granulomatous lesions of the skin in dogs, horses, and cats, and of the gastrointestinal tract in dogs. Quantitation of anti-P. insidiosum IgG antibodies can be used in dogs to both confirm a suspected diagnosis and to monitor response to therapy. Recently, an immunotherapeutic product (IP) has been marketed for the treatment of pythiosis in dogs, horses, and people. The aim of this study was to evaluate the effect of administration of this product on anti-P. insidiosum IgG concentrations in dogs. The IP was administered to seven, healthy hound mixes on …
Pharmacokinetics Of Micronized Progesterone Administration In Female Dogs, Raphael Anthony Malbrue
Pharmacokinetics Of Micronized Progesterone Administration In Female Dogs, Raphael Anthony Malbrue
LSU Master's Theses
Hypoluteoidism in the bitch is described as a reproductive condition in which insufficient levels of endogenous progesterone are present resulting in failure to maintain a functional secretory endometrium. This condition can prevent normal embryo implantation, development, and ultimately end in pregnancy loss. Hypoluteoidism in the bitch is a rising concern in small animal theriogenology and current medical therapies available to veterinarians are limited. The aim of this study was to determine the pharmacokinetics (PK) of intravaginally (Crinone®, Serono Laboratories, Norwell, MA) and orally delivered micronized progesterone (Prometrium®, Solvay Pharmaceuticals, Inc., Marietta, GA) in the bitch. We hypothesized that both vaginal …