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Natural Killer Cell Activity And Beta-Endorphin In The Mink (Mustela Vison) And The In Vitro Effect Of Beta-Endorphin In Immunologic Assays, Nancy Cathleen Pace

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to investigate natural killer cell activity and the possible role of beta- endorphin in a natural model of autoimmune orchitis, the dark mink.

An assay was developed to study natural killer cell activity in the mink and base-line levels of activity in this specie were determined. Natural killer cell activity was assessed in fertile mutation mink, primary infertile dark mink and secondary infertile Utah dark mink with autoimmune orchitis. The study included three sampling times: November, March and April. Natural killer cell activity was significantly lower in mink studied in April than it was …

Effects Of 3, 5, 6-Trichloro-2-Pyridinol On Thyroid Function, Charles Franklin Luke

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

3,5,6-trichloro-2-pyridinol, when administered in the diet, increases the feed efficiency (the ratio of weight gain to feed consumed) in various species of domestic animals and also appears to be retained in the liver at low concentrations, possibly by binding to a specific macromolecule. Because of its structural similarities to the outer ring of the thyroid hormones, trichloropyridinol and three structural analogs (2,4,5-trichlorophenol, 4-bromo-2,5-dichlorophenol, or 4-iodo-2,5-dichlorophenol) were tested for ability to compete in vitro with 3,5,3'-triiodothyronine (T₃) for nuclear receptors specific for the thyroid hormones. All four of the halogenated compounds were found to be weakly competitive for the …