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Par2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis In Mice, Shannon M. Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E. Hall, Lisa M. Mckinney, Nathan Robbins, Joel Thompson, Abigail D. Peairs, Eric Camerer, Katey J. Rayner, Michael Tranter, Nigel Mackman, A. Phillip Owens
Par2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis In Mice, Shannon M. Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E. Hall, Lisa M. Mckinney, Nathan Robbins, Joel Thompson, Abigail D. Peairs, Eric Camerer, Katey J. Rayner, Michael Tranter, Nigel Mackman, A. Phillip Owens
Exercise and Sport Studies: Faculty Publications
Objective-PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis. Approach and Resutle-PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma versus control carotid and aortic arch arteries, respectively. To determine the effect of PAR2 deficiency on atherosclerosis, male and female low-density lipoprotein receptor-deficient (Ldlr-/-) mice (8-12 weeks old) that were Par2+/+ or Par2-/- were fed a fat-and cholesterol-enriched diet for 12 or 24 weeks. …