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Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma In Mice, Amanda L. Brown, Kelsey Conrad, Daniela S. Allende, Anthony D. Gromovsky, Renliang Zhang, Chase K. Neumann, A. Phillip Owens, Michael Tranter, Robert N. Helsley
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma In Mice, Amanda L. Brown, Kelsey Conrad, Daniela S. Allende, Anthony D. Gromovsky, Renliang Zhang, Chase K. Neumann, A. Phillip Owens, Michael Tranter, Robert N. Helsley
Exercise and Sport Studies: Faculty Publications
Background: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death in the world. Choline deficiency has been well studied in the context of liver disease; however, less is known about the effects of choline supplementation in HCC. Objective: The objective of this study was to test whether choline supplementation could influence the progression of HCC in a high-fat-diet (HFD)-driven mouse model. Methods: Four-day-old male C57BL/6J mice were treated with the chemical carcinogen, 7,12-dimethylbenz[a]anthracene, and were randomly assigned at weaning to a cohort fed an HFD (60% kcal fat) or an HFD with supplemental choline (60% kcal fat, …
Sensorimotor Function In Progressive Multiple Sclerosis, Jules D. Miehm, John Buonaccorsi, Jongil Lim, Sumire Sato, Caitlin Rajala, Julianna Averill, Farnaz Khalighinejad, Carolina Ionete, Stephanie L. Jones, Jane A. Kent, Richard E.A. Van Emmerik
Sensorimotor Function In Progressive Multiple Sclerosis, Jules D. Miehm, John Buonaccorsi, Jongil Lim, Sumire Sato, Caitlin Rajala, Julianna Averill, Farnaz Khalighinejad, Carolina Ionete, Stephanie L. Jones, Jane A. Kent, Richard E.A. Van Emmerik
Exercise and Sport Studies: Faculty Publications
Background: A sensitive test reflecting subtle sensorimotor changes throughout disease progression independent of mobility impairment is currently lacking in progressive multiple sclerosis.
Objectives: We examined non-ambulatory measures of upper and lower extremity sensorimotor function that may reveal differences between relapsing–remitting and progressive forms of multiple sclerosis.
Methods: Cutaneous sensitivity, proprioception, central motor function and mobility were assessed in 32 relapsing–remitting and 31 progressive multiple sclerosis patients and 30 non-multiple sclerosis controls.
Results: Cutaneous sensation differed between relapsing–remitting and progressive multiple sclerosis at the foot and to a lesser extent the hand. Proprioception function in the upper but not the lower …