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Effect Of Age On Abrs In Mice With Epha4 Mutations, Melissa M. Teller
Effect Of Age On Abrs In Mice With Epha4 Mutations, Melissa M. Teller
Dissertations, 2014-2019
It is known that EphA4 can influence the establishment of tonotopic pathways in the auditory system. This can be measured by an increase in thresholds on the auditory brainstem response test (ABR) in mice. It is also known that the aging population in humans tends to have poorer thresholds in the high frequency sounds as they age, termed presbycusis or age-related hearing loss. The C57BL/6J background strain of mice that is known to experience a presbycusis-like process, although it is not specified when this process begins and how it progresses through their life span. The goal of this study was …