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The Role Of Enampt-Mediated Systemic Nad+ Biosynthesis In Aging And Lifespan, Mitsukuni Yoshida
The Role Of Enampt-Mediated Systemic Nad+ Biosynthesis In Aging And Lifespan, Mitsukuni Yoshida
Arts & Sciences Electronic Theses and Dissertations
Aging is a systemic decline in tissue functions that occurs during the course of our life leading to the development of age-associated health deteriorations and ultimately to the expiration of life. Over the past few decades, population aging has become increasingly evident in many parts of the world, leading to increased prevalence of age-related disabilities and diseases. Because age is a major risk factor for many chronic diseases, extensive research effort has been spent to identify common age-associated molecular changes contributing to the pathogenesis and progression of these health issues. One such molecule identified to play a central role in …
Testing The Common-Mechanisms Theory Of False Hearing And False Memory: The Roles Of Executive Functioning And Inhibitory Control, Eric Failes
Arts & Sciences Electronic Theses and Dissertations
Recent studies have shown that older adults are more susceptible to context-based misperceptions in hearing than are younger adults, a phenomenon that has been referred to as false hearing (Rogers et al., 2012; Sommers et al., 2015). The authors of these studies have noted similarities between false hearing and false memories (Jacoby et al., 2005), suggesting that the two phenomena may arise from similar cognitive mechanisms. The present dissertation project investigated similarities between false hearing and false memories. In Experiment 1, I directly compared susceptibility to false hearing and false memories in younger and older adults. I then investigated two …
Mechanics Of Phenotypic Aging Trajectories In C. Elegans And Humans, William Zhang
Mechanics Of Phenotypic Aging Trajectories In C. Elegans And Humans, William Zhang
Arts & Sciences Electronic Theses and Dissertations
Overall, my dissertation integrates longitudinal measurements of physiology to investigate the aging process. In the first half, I examine the surprising and largely unexplained degree of variation in lifespan within even homogeneous populations. I sought to understand how physiological aging differs between long- and short-lived individuals within a population of genetically identical C. elegans reared in a homogeneous environment. Using a novel culture apparatus, I longitudinally monitored aspects of aging physiology across a large population of isolated individuals. Aggregating several measures into an overall estimate of senescence, I find that long- and short-lived individuals start adulthood on an equal physiological …