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Teacher Disposition Scale (Tds): Construction And Psychometric Validation, Conor West, Amanda Ann Baker, John F. Ehrich, Stuart Woodcock, Sahar Bokosmaty, Steven J. Howard, Michelle J. Eady

Faculty of Social Sciences - Papers (Archive)

Despite the growing prominence and importance of the field of teacher dispositions for addressing selection criteria and assessment in educational research, there is an absence of psychometrically evaluated instruments to facilitate investigations. Furthermore, research thus far has not explored the relationship between teacher dispositions and better student outcomes. To address this paucity, key dispositional factors conducive to successful teaching and learning were identified through interviewing high performing teachers. Based on the interview, data a 24-item Teacher Disposition Scale (TDS) was constructed consisting of five dimensions: Motivation to teach; Teacher efficacy; Willingness to learn; Conscientiousness; and Interpersonal and communication skill. The …

Development And Validation Of A Written Credentialing Examination For Overseas-Educated Dietitians, Neville G. Chiavaroli, Eleanor J. Beck, Catherine Itsiopoulos, Paul Wilkinson, Kay Gibbons, Claire Palermo

Faculty of Science, Medicine and Health - Papers: part A

Aim Health professionals seeking employment in foreign countries are commonly required to undertake competency assessment in order to practice. The present study aims to outline the development and validation of a written examination for Dietetic Skills Recognition (DSR), to assess the knowledge, skills, capabilities and professional judgement of overseas-educated dietitians against the competency standards applied to dietetic graduates in Australia. Methods The present study reviews the design, rationale, validation and outcomes of a multiple choice question (MCQ) written examination for overseas-educated dietitians based on 5 years of administration. The validity of the exam is evaluated using Messick's validity framework, which …

Development And Validation Of A Method To Evaluate The Penetration Of Diesel Particulate Matter Through Respirator Filter Media, At Flow Rates Representative Of Moderate To Heavy Work, Kerrie Burton, Jane L. Whitelaw, Alison L. Jones, Brian Davies

Faculty of Social Sciences - Papers (Archive)

Poster presentation at The 18th International Conference of International Society for Respiratory Protection, 7-11 November 2016, Yokohama, Japan.

First-Stage Development And Validation Of A Web-Based Automated Dietary Modeling Tool: Using Constraint Optimization Techniques To Streamline Food Group And Macronutrient Focused Dietary Prescriptions For Clinical Trials, Yasmine Probst, Evan Morrison, Emma Sullivan, Hoa K. Dam

Faculty of Science, Medicine and Health - Papers: part A

No abstract provided.

Validation Of 3dvh Estimated Dvh Metrics For Prostate Vmat Plans, Sankar Arumugam, Aitang Xing, Tony Young, David Thwaites, Lois C. Holloway

Faculty of Engineering and Information Sciences - Papers: Part A

The accuracy of 3DVH (Sun Nuclear Corporation, USA) reported DVH metrics for target volumes and Organs at Risk (OARs) for two Prostate Volumetric Modulated Arc Therapy (VMAT) plans was studied. The accuracy of 3DVH estimated DVH metrics in the presence of Multi Leaf Collimator (MLC) systematic errors was also tested with error introduced plans calculated in Pinnacle. The results of the study show that the DVH metrics estimated by 3DVH for error-free plans agree with the TPS calculation within 3%. The D95 to PTV was shown to be sensitive in detecting studied MLC errors. However the accuracy of 3DVH estimated …

Progress In Geant4 Electromagnetic Physics Modelling And Validation, J Apostolakis, M Asai, A Bagulya, Jeremy M. C Brown, H Burkhardt, N Chikuma, M A. Cortes-Giraldo, S Elles, V Grichine, Susanna Guatelli, Sebastian Incerti, V N. Ivanchenko, J Jacquemier, O Kadri, M Maire, L Pandola, D Sawkey, T Toshito, L Urban, T T Yamashita

Faculty of Engineering and Information Sciences - Papers: Part A

In this work we report on recent improvements in the electromagnetic (EM) physics models of Geant4 and new validations of EM physics. Improvements have been made in models of the photoelectric effect, Compton scattering, gamma conversion to electron and muon pairs, fluctuations of energy loss, multiple scattering, synchrotron radiation, and high energy positron annihilation. The results of these developments are included in the new Geant4 version 10.1 and in patches to previous versions 9.6 and 10.0 that are planned to be used for production for run-2 at LHC. The Geant4 validation suite for EM physics has been extended and new …

Learning Resources Within The Actiotope: A Validation Study Of The Qelc (Questionnaire Of Educational And Learning Capital), Anamaria Vladut, Wilma Vialle, Albert Ziegler

Faculty of Social Sciences - Papers (Archive)

In the Actiotope Model of Giftedness the important role of exogenous and endogenous learning resources (educational and learning capital) for successful learning is emphasized. However, so far no empirical evidence has been offered to establish a link between an actiotope and learning resources. An economical quantitative measuring instrument is the Questionnaire of Educational and Learning Capital (QELC). In an empirical study with a sample of 248 post-secondary school students from Germany, the empirical link between actiotope variables and learning resources was established. The results showed that the QELC has satisfactory psychometric qualities as well as acceptable factorial and concurrent validity.

Measuring Food Brand Awareness In Australian Children: Development And Validation Of A New Instrument, Laura Turner, Bridget P. Kelly, Emma J. Boyland, Adrian E. Bauman

Faculty of Social Sciences - Papers (Archive)

Background Children's exposure to food marketing is one environmental determinant of childhood obesity. Measuring the extent to which children are aware of food brands may be one way to estimate relative prior exposures to food marketing. This study aimed to develop and validate an Australian Brand Awareness Instrument (ABAI) to estimate children's food brand awareness. Methods The ABAI incorporated 30 flashcards depicting food/drink logos and their corresponding products. An abbreviated version was also created using 12 flashcards (ABAI-a). The ABAI was presented to 60 primary school aged children (7-11yrs) attending two Australian after-school centres. A week later, the full-version was …

Benchmarking And Validation Of A Geant4-Shadow Monte Carlo Simulation For Dose Calculations In Microbeam Radiation Therapy, Iwan Cornelius, Susanna Guatelli, Pauline Fournier, Jeffrey C. Crosbie, Manuel Sanchez Del Rio, Elke Brauer-Krisch, Anatoly Rosenfeld, Michael Lf Lerch

Faculty of Engineering and Information Sciences - Papers: Part A

Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including …

Reconnecting Urban Planning With Health: A Protocol For The Development And Validation Of National Liveability Indicators Associated With Noncommunicable Disease Risk Behaviours And Health Outcomes, Billie Giles-Corti, Hannah M. Badland, Suzanne Mavoa, Gavin Turrell, Fiona Bull, Bryan Boruff, Christopher Pettit, Adrian E. Bauman, Paula Hooper, Karen Villanueva, Thomas Astell-Burt, Xiaoqi Feng, Vincent Learnihan, R Davey, Rob Grenfell, Sarah Thackway

Faculty of Social Sciences - Papers (Archive)

Aim: Liveable communities create the conditions to optimise health and wellbeing outcomes in residents by influencing various social determinants of health - for example, neighbourhood walkability and access to public transport, public open space, local amenities, and social and community facilities. This study will develop national liveability indicators that are (a) aligned with state and federal urban policy, (b) developed using national data (where available), (c) standard and consistent over time, (d) suitable for monitoring progress towards creating more liveable, equitable and sustainable communities, (e) validated against selected noncommunicable disease risk behaviours and/or health outcomes, and (f) practical for measuring …

Development And Validation Of A Salt Knowledge Questionnaire, Rani Sarmugam, Anthony Worsley, Victoria Flood

Faculty of Social Sciences - Papers (Archive)

Objective Initiatives promoting the reduction of high-salt food consumption by consumers need to be partly based on current levels of salt knowledge in the population. However, to date there is no validated salt knowledge questionnaire that could be used to assess population knowledge about dietary salt (i.e. salt knowledge). Therefore, the aim of the present study was to develop and validate a salt knowledge questionnaire.

Design A cross-sectional study was conducted on an online web survey platform using convenience, snowball sampling. The survey questionnaire was evaluated for content and face validity before being administered to the respondents.

Setting Online survey. …

Development And Validation Of A Disaster Management Metamodel (Dmm), Siti Hajar Othman, Ghassan Beydoun, Vijayan Sugumaran

Faculty of Engineering and Information Sciences - Papers: Part A

Disaster Management (DM) is a diffused area of knowledge. It has many complex features interconnecting the physical and the social views of the world. Many international and national bodies create knowledge models to allow knowledge sharing and effective DM activities. But these are often narrow in focus and deal with specified disaster types. We analyze thirty such models to uncover that many DM activities are actually common even when the events vary. We then create a unified view of DM in the form of a metamodel. We apply a metamodelling process to ensure that this metamodel is complete and consistent. …

Measuring Students' Perceptions Of Plagiarism: Modification And Rasch Validation Of A Plagiarism Attitude Scale, Steven J. Howard, John F. Ehrich, Russell Walton

Faculty of Social Sciences - Papers (Archive)

Plagiarism is a significant area of concern in higher education, given university students' high self-reported rates of plagiarism. However, research remains inconsistent in prevalence estimates and suggested precursors of plagiarism. This may be a function of the unclear psychometric properties of the measurement tools adopted. To investigate this, we modified an existing plagiarism scale (to broaden its scope), established its psychometric properties using traditional (EFA, Cronbach's alpha) and modern (Rasch analysis) survey evaluation approaches, and examined results of well-functioning items. Results indicated that traditional and modern psychometric approaches differed in their recommendations. Further, responses indicated that although most respondents acknowledged …

Validation Of Activpaltm Defined Sedentary Time And Breaks In Sedentary Time In 4- To 6-Year Olds., Xanne Janssen, Dylan P. Cliff, John J. Reilly, Trina Hinkley, Rachel A. Jones, Marijka Batterham, Ulf Ekelund, Soren Brage, Anthony D. Okely

Faculty of Social Sciences - Papers (Archive)

This study examined the classification accuracy of the activPAL™, including total time spent sedentary and total number of breaks in sedentary behavior (SB) in 4-6 year old children. Forty children aged 4-6 years (5.3±1.0 years) completed a ~150-min laboratory protocol involving sedentary, light and moderate-to vigorous-intensity activities. Posture was coded as sit/lie, stand, walk or 'other' using direct observation. Posture was classified using the activPAL™ software. Classification accuracy was evaluated using sensitivity, specificity and area under the receiver operating characteristic curve (ROC-AUC). Time spent in each posture and total number of breaks in SB were compared using paired sample t-tests. …

A Cross-Cultural Validation Study Of The Questionnaire Of Educational And Learning Capital (Qelc) In China, Germany And Turkey, Anamaria Vladut, Qian Liu, Marilena Z. Leana-Tascila, Wilma Vialle, Albert Ziegler

Faculty of Social Sciences - Papers (Archive)

Unlike traditional person-centered models of giftedness, the Actiotope Model of Giftedness focuses on the person-environment interactions. It postulates that successful learning requires necessary resources, termed educational and learning capital, located both in the environment and the individual. The Questionnaire of Educational and Learning Capital (QELC) is introduced. The results of a validation study with students from China, Turkey and Germany is reported which shows that the QELC has satisfactory psychometric properties as well as construct and concurrent validity.

Validation Of An Imrt Beam Model Using A Secondary Treatment Planning System As A 3d Dosimeter, A Xing, S Arumugam, L Holloway, G Goozee

Faculty of Engineering and Information Sciences - Papers: Part A

A treatment planning system IMRT beam model is usually validated using phantom-based measurement, however this will not detect errors related to patient anatomy and inhomogeneity. In this study a secondary treatment system (CMS XIO) was used as a 3D dosimeter to verify an IMRT beam model recently commissioned in a Philips Pinnacle treatment planning system. Data sets from three head-neck and two prostate patients previously treated were utilised. The IMRT plans for these patients were planned in Pinnacle and transferred to XIO. The dose at each voxel in the patient volume was calculated in both XIO and Pinnacle. The 2D …

Development And Validation Of An Insulin Proficiency Assessment Tool For Insulin Self-Management In Adults With Type 2 Diabetes Mellitus, Dianna Fornasier, Andrew Bonney

Faculty of Science, Medicine and Health - Papers: part A

No abstract provided.

Validation Of The Dynamic Direct Exposure Method For Toxicity Testing Of Diesel Exhaust In Vitro, Lucky Joeng, Amanda Hayes, Shahnaz Bakand

Faculty of Social Sciences - Papers (Archive)

Diesel exhaust emission is a major health concern because of the complex nature of its gaseous content (e.g., NO₂, NO, CO, and CO₂) and high concentration of particulate matter (PM) less than 2.5 μm which allows for deeper penetration into the human pulmonary system upon inhalation. The aim of this research was to elucidate the potential toxic effects of diesel exhaust on a human pulmonary-based cellular system. Validation of a dynamic direct exposure method for both laboratory (230 hp Volvo truck engine) and field (Volkswagen Passat passenger car) diesel engines, at idle mode, was implemented. Human …

Approaches To Establishing A Metadata Standard For Field Spectroscopy Datasets, Barbara A. Rasaiah, Tim J. Malthus, Chris Bellman, Laurie Chisholm, John Gamon, Andreas Hueni, Alfredo Huete, Simon D. Jones, Cindy Ong, Stuart Phinn, Chris Roelfsema, Lola Suarez, Philip Townsend, Rebecca Trevithick, Mat Wyatt

Faculty of Science, Medicine and Health - Papers: part A

There is an urgent need within the international remote sensing community to establish a metadata standard for field spectroscopy that ensures high quality, interoperable metadata sets that can be archived and shared efficiently within Earth observation data sharing systems. Careful examination of all stages of metadata collection and analysis can inform a robust standard that is applicable to a range of field campaigns. This paper presents approaches towards a standard that encompasses in situ metadata collection and initiatives towards sharing metadata within intelligent archiving systems.

Improvement Of The Retrieval Algorithm For Gosat Swir Xco2 And Xch4 And Their Validation Using Tccon Data, Y Yoshida, N Kikuchi, I Morino, O Uchino, S Oshchepkov, A Bril, T Saeki, N Schutgens, G C. Toon, D Wunch, C M. Roehl, P O. Wennberg, D W. T Griffith, N M. Deutscher, T Warneke, J Notholt, J Robinson, V Sherlock, B Connor, M Rettinger, R Sussmann, P Ahonen, P Heikkinen, E Kyro, J Mendonca, K Strong, F Hase, S Dohe, T Yokota

Faculty of Science, Medicine and Health - Papers: part A

The column-averaged dry-air mole fractions of carbon dioxide and methane (XCO2 and XCH4) have been retrieved from Greenhouse gases Observing SATellite (GOSAT) Short-Wavelength InfraRed (SWIR) observations and released as a SWIR L2 product from the National Institute for Environmental Studies (NIES). XCO2 and XCH4 retrieved using the version 01.xx retrieval algorithm showed large negative biases and standard deviations (−8.85 and 4.75 ppm for XCO2 and −20.4 and 18.9 ppb for XCH4, respectively) compared with data of the Total Carbon Column Observing Network (TCCON). Multiple reasons for these error characteristics (e.g., solar irradiance database, handling of aerosol scattering) are identified and …

I-125 Ropes Eye Plaque Dosimetry: Validation Of A Commercial 3d Ophthalmic Brachytherapy Treatment Planning System And Independent Dose Calculation Software With Gafchromic Ebt3 Films, Joel Poder, Stephanie Corde

Faculty of Engineering and Information Sciences - Papers: Part A

Purpose: The purpose of this study was to measure the dose distributions for different Radiation Oncology Physics and Engineering Services, Australia (ROPES) type eye plaques loaded with I-125 (model 6711) seeds using GafChromic R EBT3 films, in order to verify the dose distributions in the Plaque SimulatorTM (PS) ophthalmic 3D treatment planning system. The brachytherapy module of RADCALC R was used to independently check the dose distributions calculated by PS. Correction factors were derived from the measured data to be used in PS to account for the effect of the stainless steel ROPES plaque backing on the 3D dose distribution. …

Clinical Validation Of An In-House Epid Dosimetry System For Imrt Qa At The Prince Of Wales Hospital, M Tyler, P Vial, P Metcalfe, S Downes

Faculty of Engineering and Information Sciences - Papers: Part A

In this study a simple method using standard flood-field corrected Electronic Portal Imaging Device (EPID) images for routine Intensity Modulated Radiation Therapy (IMRT) Quality Assurance (QA) was investigated. The EPID QA system was designed and tested on a Siemens Oncor Impression linear accelerator with an OptiVue 1000ST EPID panel (Siemens Medical Solutions USA, Inc, USA) and an Elekta Axesse linear accelerator with an iViewGT EPID (Elekta AB, Sweden) for 6 and 10 MV IMRT fields with Step-and-Shoot and dynamic-MLC delivery. Two different planning systems were used for patient IMRT field generation for comparison with the measured EPID fluences. All measured …

Validation Of The Differentiated Transformational Leadership Inventory As A Measure Of Coach Leadership In Youth Soccer, Stewart A. Vella, Lindsay G. Oades, Trevor P. Crowe

Faculty of Health and Behavioural Sciences - Papers (Archive)

This paper describes the validation of The Differentiated Transformational Leadership Inventory (DTLI) within a participation youth sports context. Three hundred and twenty-two athletes aged between 11 and 18 years completed the DTLI. Using a confirmatory factor analysis, the DTLI yielded an underlying factor structure that fell short of cut-off criteria for adjudging model fit. Subsequent theory-driven changes were made to the DTLI by removing the 'high performance expectations' subscale. Further data-driven changes were also made on the basis of high item-factor cross-loadings. The revised version of the DTLI was subjected to confirmatory factor analysis and proved to be a good …

Validation Of Iasi Forli Carbon Monoxide Retrievals Using Ftir Data From Ndacc, T Kerzenmacher, B Dils, N Kumps, T Blumenstock, C Clerbaux, P F. Coheur, P Demoulin, Omaira Garcia, M George, David W. Griffith, F Hase, J Hadji-Lazaro, D Hurtmans, Nicholas B. Jones, E Mahieu, Justus Notholt, Clare Paton-Walsh, U Raffalski, T Ridder, M Schneider, C Servais, M De Maziere

Faculty of Science - Papers (Archive)

Carbon monoxide (CO) is retrieved daily and globally from space-borne IASI radiance spectra using the Fast Optimal Retrievals on Layers for IASI (FORLI) software developed at the Universit´e Libre de Bruxelles (ULB). The IASI CO total column product for 2008 from the most recent FORLI retrieval version (20100815) is evaluated using correlative CO profile products retrieved from groundbased solar absorption Fourier transform infrared (FTIR) observations at the following FTIR spectrometer sites from the Network for the Detection of Atmospheric Composition Change (NDACC): Ny-A° lesund, Kiruna, Bremen, Jungfraujoch, Iza˜na and Wollongong. In order to have good statistics for the comparisons, we …

Effects Of Atmospheric Light Scattering On Spectroscopic Observations Of Greenhouse Gases From Space: Validation Of Ppdf-Based Co 2 Retrievals From Gosat, Sergey Oshchepkov, Andrey Bril, Tatsuya Yokota, Isamu Morino, Yukio Yoshida, Tsuneo Matsunaga, Dmitry Belikov, Debra Wunch, Paul Wennberg, Geoffrey Toon, Christopher O'Dell, André Butz, Sandrine Guerlet, Austin Cogan, Hartmut Boesch, Nawo Eguchi, Nicholas Deutscher, David Griffith, Ronald Macatangay, Justus Notholt, Ralf Sussmann, Markus Rettinger, Vanessa Sherlock, John Robinson, Esko Kyro, Pauli Heikkinen, Dietrich G. Feist, Tomoo Nagahama, Nikolay Kadygrov, Shamil Maksyutov, Osamu Uchino, Hiroshi Watanabe

Faculty of Science - Papers (Archive)

This report describes a validation study of Greenhouse gases Observing Satellite (GOSAT) data processing using ground-based measurements of the Total Carbon Column Observing Network (TCCON) as reference data for column-averaged dry air mole fractions of atmospheric carbon dioxide (X CO2). We applied the photon path length probability density function method to validate X CO2 retrievals from GOSAT data obtained during 22months starting from June 2009. This method permitted direct evaluation of optical path modifications due to atmospheric light scattering that would have a negligible impact on ground-based TCCON measurements but could significantly affect gas retrievals when observing reflected sunlight from …

Development And Validation Of A Concept Inventory For Introductory-Level Climate Change Science, Lorna Jarrett, Brian Ferry, George Takacs

Faculty of Engineering and Information Sciences - Papers: Part A

This paper follows on from Jarrett, Takacs and Ferry (2011) which reported the first stage in development of a high school level concept inventory (CI) for the science of climate change: the climate change concept inventory (CCCI). In order to develop a reliable and valid instrument, it is necessary to follow appropriate procedures. This paper details the process of CI item development; reports statistical results of initial field trials and outlines how these will be used to further refine the CCCI. Item difficulty, discrimination, and point biserial coefficient were calculated for each item. Cronbach's alpha and test-retest data were used …

Development And Validation Of An Australian Database For Estimating The Seafood Content Of Canned Products, Elizabeth Neale, Yasmine Probst, Marijka Batterham, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Canned fish products are of increasing popularity in Australia; however current Australian nutrient databases do not include data on the percentage fish in these products. The objective of this study was to develop and validate a database of the percentage fish and seafood contained in common canned fish and seafood products, for use in clinical trials. Six major supermarkets in the Illawarra region, NSW were audited for canned seafood products, and a database of re-ported percentage fish and seafood was developed. Mean + SD of each type of product was then determined. To vali-date the database, a representative sample of …

Retrieval Of Atmospheric Co2 With Enhanced Accuracy And Precision From Sciamachy: Validation With Fts Measurements And Comparison With Model Results, M Reuter, H Bovensmann, M Buchwitz, Jp Burrows, B Connor, Nicholas M. Deutscher, David W. Griffith, J Heymann, Gretchen Keppel-Aleks, Janina Messerschmidt, Justus Notholt, Christof Petri, J Robinson, O Schneising, V Sherlock, Voltaire A. Velazco, Thorsten Warneke, Paul O. Wennberg, Debra Wunch

Faculty of Science - Papers (Archive)

The Bremen Optimal Estimation differential optical absorption spectroscopy (DOAS) (BESD) algorithm for satellite based retrievals of XCO 2 (the column-average dry-air mole fraction of atmospheric CO 2) has been applied to Scanning Imaging Absorption Spectrometer for Atmospheric Cartography (SCIAMACHY) data. It uses measurements in the O 2-A absorption band to correct for scattering of undetected clouds and aerosols. Comparisons with precise and accurate ground-based Fourier transform spectrometer (FTS) measurements at four Total Carbon Column Observing Network (TCCON) sites have been used to quantify the quality of the new SCIAMACHY XCO 2 data set. Additionally, the results have been compared to …

Preliminary Validation Of Column-Averaged Volume Mixing Ratios Of Carbon Dioxide And Methane Retrieved From Gosat Short-Wavelength Infrared Spectra, David W. Griffith, G C. Toon, B Connor, R Sussmann, Thorsten Warneke, Nicholas M. Deutscher, Paul O. Wennberg, Justus Notholt, V Sherlock, J Robinson, O Uchino, C M. Roehl, I Morino, Debra Wunch, Janina Messerschmidt, Y Yoshida, M Inoue, M Rettinger

Faculty of Science - Papers (Archive)

Column-averaged volume mixing ratios of carbon dioxide and methane retrieved from the Greenhouse gases Observing SATellite (GOSAT) Short-Wavelength InfraRed observation (GOSAT SWIR XCO2 and XCH4 ) were compared with the reference calibrated data obtained by ground-based high-resolution Fourier Transform Spectrometers (g-b FTSs) participating in the Total Carbon Column Observing Network (TCCON). Preliminary results are as follows: the GOSAT SWIR XCO2 and XCH4 (Version 01.xx) are biased low by 8.85 ±4.75 ppm (2.3±1.2 %) and 20.4±18.9 ppb (1.2±1.1 %), respectively. The standard deviation of the GOSAT SWIR XCO2 and XCH4 is about 1% after correcting the negative biases of XCO2 and …

Identification Of Serpina1 As Single Marker For Papillary Thyroid Carcinoma Through Microarray Meta Analysis And Quantification Of Its Discriminatory Power In Independent Validation, Klemens Vierlinger, Markus H. Mansfeld, Oskar Koperek, Christa Nöhammer, Klaus Kaserer, Friedrich Leisch

Faculty of Commerce - Papers (Archive)

Background Several DNA microarray based expression signatures for the different clinically relevant thyroid tumor entities have been described over the past few years. However, reproducibility of these signatures is generally low, mainly due to study biases, small sample sizes and the highly multivariate nature of microarrays. While there are new technologies available for a more accurate high throughput expression analysis, we show that there is still a lot of information to be gained from data deposited in public microarray databases. In this study we were aiming (1) to identify potential markers for papillary thyroid carcinomas through meta analysis of public …