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Effects Of Δ9-Tetrahydrocannabinol Administration On Human Encoding And Recall Memory Function: A Pharmacological Fmri Study, Matthijs G. Bossong, Gerry Jager, Hendrika H. Van Hell, Lineke Zuurman, J Martijn Jansma, Mitul A. Mehta, Joop M. A Van Gerven, Rene S. Kahn, Nick F. Ramsey
Effects Of Δ9-Tetrahydrocannabinol Administration On Human Encoding And Recall Memory Function: A Pharmacological Fmri Study, Matthijs G. Bossong, Gerry Jager, Hendrika H. Van Hell, Lineke Zuurman, J Martijn Jansma, Mitul A. Mehta, Joop M. A Van Gerven, Rene S. Kahn, Nick F. Ramsey
Faculty of Social Sciences - Papers (Archive)
Deficits in memory function are an incapacitating aspect of various psychiatric and neurological disorders. Animal studies have recently provided strong evidence for involvement of the endocannabinoid (eCB) system in memory function. Neuropsychological studies in humans have shown less convincing evidence but suggest that administration of cannabinoid substances affects encoding rather than recall of information. In this study, we examined the effects of perturbation of the eCB system on memory function during both encoding and recall. We performed a pharmacological MRI study with a placebo-controlled, crossover design, investigating the effects of Δ9-tetrahydrocannabinol (THC) inhalation on associative memory-related brain function in 13 …