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Association Between The Magnitude Of The Immune Response And Recurrent Major Depression Disorder In Humans And Depression-Like Behavior In Animals, Anastacia Kudinova
Association Between The Magnitude Of The Immune Response And Recurrent Major Depression Disorder In Humans And Depression-Like Behavior In Animals, Anastacia Kudinova
Graduate Dissertations and Theses
There is a growing body of evidence supporting the association between inflammation and major depressive disorder (MDD). One plausible mechanism for this association is sensitization of the immune response, possibly due to prior exposure to stressors. To investigate the validity of this hypothesis, a series of three complimentary cross-species studies was conducted. Study 1 examined the associations between circulating levels of inflammatory markers and in vitro immune reactivity with women’s history of recurrent MDD (rMDD) and their current symptoms of anhedonia. The potential moderating role of women’s history of childhood abuse was also examined. Study 2 and 3 focused on …