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Social and Behavioral Sciences

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Selected Works

2005

Depression

Articles 1 - 5 of 5

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Preliminary Evidence For Medication Effects On Functional Abnormalities In The Amygdala And Anterior Cingulate In Bipolar Disorder, Hilary P. Blumberg, Nelson H. Donegan, Charles A. Sanislow, Susan Collins, Cheryl Lacadie, Pawel Skudlarski, Ralitza Gueorguieva, Robert K. Fulbright, Thomas H. Mcglashan, John C. Gore, John H. Krystal Nov 2005

Preliminary Evidence For Medication Effects On Functional Abnormalities In The Amygdala And Anterior Cingulate In Bipolar Disorder, Hilary P. Blumberg, Nelson H. Donegan, Charles A. Sanislow, Susan Collins, Cheryl Lacadie, Pawel Skudlarski, Ralitza Gueorguieva, Robert K. Fulbright, Thomas H. Mcglashan, John C. Gore, John H. Krystal

Charles A. Sanislow, Ph.D.

RATIONALE: Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets.

OBJECTIVES: The aim of this study was to investigate amygdala and frontocortical responses to emotional face stimuli in BD and the influences of mood-stabilizing medications on these responses.

METHODS: Functional magnetic resonance imaging was performed while 17 BD participants (5 unmedicated) and 17 healthy comparison (HC) participants viewed faces with happy, sad, fearful, or neutral expressions.

RESULTS: The group by stimulus-condition interaction was significant (p<0.01) for amygdala activation, with the greatest effects in the happy face condition. Relative to HC, amygdala increases were greater in unmedicated BD, but lower in medicated BD. Rostral anterior cingulate (rAC) activation was decreased in unmedicated BD compared to HC; however, BD participants taking medication demonstrated rAC activation similar to HC participants.

CONCLUSIONS: Although the sample sizes were small, these preliminary results suggest that …

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Longitudinal Comparison Of Depressive Personality Disorder And Dysthymic Disorder, John C. Markowitz, Andrew E. Skodol, Eva Petkova, Hui Xie, Jianfeng Cheng, David J. Hellerstein, John G. Gunderson, Charles A. Sanislow, Carlos M. Grilo, Thomas H. Mcglashan Jun 2005

Longitudinal Comparison Of Depressive Personality Disorder And Dysthymic Disorder, John C. Markowitz, Andrew E. Skodol, Eva Petkova, Hui Xie, Jianfeng Cheng, David J. Hellerstein, John G. Gunderson, Charles A. Sanislow, Carlos M. Grilo, Thomas H. Mcglashan

Charles A. Sanislow, Ph.D.

BACKGROUND: Few studies have compared the related diagnostic constructs of depressive personality disorder (DPD) and dysthymic disorder (DD). The authors attempted to replicate findings of Klein and Shih in longitudinally followed patients with personality disorder or major depressive disorder (MDD) in the Collaborative Longitudinal Personality Disorders Study.

METHODS: Subjects (N = 665) were evaluated at baseline and over 2 years (n = 546) by reliably trained clinical interviewers using semistructured interviews and self-report personality questionnaires.

RESULTS: Only 44 subjects (24.6% of 179 DPD and 49.4% of 89 early-onset dysthymic subjects) met criteria for both disorders at baseline. Depressive personality disorder …

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Prevalence And Comorbidity Of Major Depressive Disorder In Young Black And White Women., Ruth Striegel Weissman Dec 2004

Prevalence And Comorbidity Of Major Depressive Disorder In Young Black And White Women., Ruth Striegel Weissman

Ruth Striegel Weissman

Objective
This study reports the prevalence and comorbidity of depression in two large samples of black and white young adult women.
Method
Clinical interviews of participants in a follow-up study of the National Heart, Lung, and Blood Institute Growth and Health Study (NGHS-Wave II; N = 378) were contrasted with a subsample of the National Comorbidity Survey (NCS; N = 3749) to examine the rates and comorbidity of lifetime major depressive disorder in black and white women using methodology described by Kraemer (1995). The sequencing of disorders was also examined to determine which disorder was primary. Comorbidity and sequencing were examined …

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Self-Reported Symptoms Of Depression In Late Adolescence: A Comparison Of Black And White Females, Ruth Striegel Weissman Dec 2004

Self-Reported Symptoms Of Depression In Late Adolescence: A Comparison Of Black And White Females, Ruth Striegel Weissman

Ruth Striegel Weissman

The prevalence of depressive symptoms from adolescence through young adulthood was examined in 1,146 African-American adolescent girls and 1,075 Caucasian adolescent girls who completed the Center for Epidemiological Studies of Depression scale. Caucasian girls’ scores decreased over time, whereas scores for African-American girls were fairly consistent. Future studies are needed to examine age-specific risk factors in adolescent girls.

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Psychosocial And Health Consequences Of Adolescent Depression In Black And White Young Adult Women, Ruth Striegel Weissman Dec 2004

Psychosocial And Health Consequences Of Adolescent Depression In Black And White Young Adult Women, Ruth Striegel Weissman

Ruth Striegel Weissman

Depression in adolescent girls may result in negative consequences in young adulthood. The Center for Epidemiologic Studies Depression Scale (CES-D) was administered to 1,727 Black and White girls ages 16 to 18 years who participated in the National Heart, Lung, and Blood Institute's Growth and Health Study. Three years later, women in the depressed groups were more likely to be current smokers, had attained a lower level of education, and reported lower self-worth relative to the nondepressed group. Body dissatisfaction, eating concerns, and loneliness were greater in the depressed groups. Relative to Black women, White women who were moderately depressed …

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