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Early Exposure To Traumatic Stressors Impairs Emotional Brain Circuitry, Robert H. Paul, Mayuresh S. Korgaonkar, Cassandra Antees, Leanne M. Williams
Early Exposure To Traumatic Stressors Impairs Emotional Brain Circuitry, Robert H. Paul, Mayuresh S. Korgaonkar, Cassandra Antees, Leanne M. Williams
Psychology Faculty Works
Exposure to early life trauma (ELT) is known to have a profound impact on mental development, leading to a higher risk for depression and anxiety. Our aim was to use multiple structural imaging methods to systematically investigate how traumatic stressors early in life impact the emotional brain circuits, typically found impaired with clinical diagnosis of depression and anxiety, across the lifespan in an otherwise healthy cohort. MRI data and self-reported histories of ELT from 352 healthy individuals screened for no psychiatric disorders were analyzed in this study. The volume and cortical thickness of the limbic and cingulate regions were assessed …
Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda
Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda
Psychology Faculty Works
Objectives Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to determine if the level of HIV DNA in CD14+ enriched monocytes predicted cognitive impairment and brain injury. Methods We enrolled 61 cART-naïve HIV-infected Thais in a prospective study and measured HIV DNA in CD14+ enriched monocyte samples in a blinded fashion. We determined HAND diagnoses by consensus panel and all participants underwent magnetic resonance spectroscopy (MRS) …
The Role Of Anxiety In Binge Eating Behavior: A Critical Examination Of Theory And Empirical Literature, Kamila S. White, Diane L. Rosenbaum
The Role Of Anxiety In Binge Eating Behavior: A Critical Examination Of Theory And Empirical Literature, Kamila S. White, Diane L. Rosenbaum
Psychology Faculty Works
The purpose of this manuscript is to expand the understanding of binge eating by reviewing the role of aspects of negative affect. Specifically, this paper will present evidence for further investigation of the bearing that anxiety may have in binge eating development and maintenance. A comprehensive review of the literature regarding the relation of binge eating and anxiety was performed. Valuable contributions have been made to the binge eating literature regarding some aspects of negative affect (i.e., depression); however, outside of bulimia nervosa studies, much of the theoretical and empirical binge eating research to date has not directly addressed the …
The Utility Of Cancer-Related Cultural Constructs To Understand Colorectal Cancer Screening Among African Americans, John P. Meriac, Vetta L. S. Thompson, Alan Bugbee, Jenine K. Harris
The Utility Of Cancer-Related Cultural Constructs To Understand Colorectal Cancer Screening Among African Americans, John P. Meriac, Vetta L. S. Thompson, Alan Bugbee, Jenine K. Harris
Psychology Faculty Works
Data suggest that colorectal cancer could be cut by approximately 60% if all people aged 50 years or older received regular screening. Studies have identified socio-cultural attitudes that might inform cancer education and screening promotion campaigns. This article applies item response theory (IRT) to a set of survey items selected to assess sociocultural attitudes in order to determine how current measures may affect what we know about how these attitudes affect colorectal cancer screening (CRCS). Design and Methods. A survey of colorectal cancer screening, screening attitudes and cultural beliefs was administered to 1021 African Americans - 683 women and 338 …
Altered Emotional Interference Processing In The Amygdala And Insula In Women With Post-Traumatic Stress Disorder, Steven E. Bruce, Katherine R. Buchholz, Wilson J. Brown, Laura Yan
Altered Emotional Interference Processing In The Amygdala And Insula In Women With Post-Traumatic Stress Disorder, Steven E. Bruce, Katherine R. Buchholz, Wilson J. Brown, Laura Yan
Psychology Faculty Works
Background: Post-Traumatic Stress Disorder (PTSD) is characterized by distinct behavioral and physiological changes. Given the significant impairments related to PTSD, examination of the biological underpinnings is crucial to the development of theoretical models and improved treatments of PTSD. Methods: We used an attentional interference task using emotional distracters to test for top-down versus bottom-up dysfunction in the interaction of cognitive-control circuitry and emotion-processing circuitry. A total of 32 women with PTSD (based on an interpersonal trauma) and 21 matched controls were tested. Event-related functional magnetic resonance imaging was carried out as participants directly attended to, or attempted to ignore, fear-related …