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Diffusion Tensor Imaging In Hiv And Hepatitis C Coinfection, Jodi Michelle Heaps
Diffusion Tensor Imaging In Hiv And Hepatitis C Coinfection, Jodi Michelle Heaps
Dissertations
Previous studies have demonstrated that infection with both human immune deficiency virus (HIV) and hepatitis C (HCV) is associated with impaired cognitive function. It is unclear whether co-infection is associated with neuroimaging markers of brain dysfunction. The purpose of the present study was to compare HIV+ individuals, HIV/HCV+ individuals, and seronegative controls using diffusion tensor imaging (DTI) to assess the microstructural integrity of white matter tissue. Methods: Twenty-five HIV+ patients, 25 HIV/HCV+ patients, and 25 seronegative controls matched for age were included in the study. All participants completed an MRI session, neuropsychological testing, and an evaluation of clinical variables including …
Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda
Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda
Psychology Faculty Works
Objectives Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to determine if the level of HIV DNA in CD14+ enriched monocytes predicted cognitive impairment and brain injury. Methods We enrolled 61 cART-naïve HIV-infected Thais in a prospective study and measured HIV DNA in CD14+ enriched monocyte samples in a blinded fashion. We determined HAND diagnoses by consensus panel and all participants underwent magnetic resonance spectroscopy (MRS) …