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Segregation Of A Latent High Adiposity Phenotype In Families With A History Of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants With Large Effects In Diabetes-Related Obesity, Arthur B. Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell

Dr Marijka Batterham

Background We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1st degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH−) during voluntary overfeeding, implying co-inheritance of susceptibilities to T2DM and obesity. We have estimated the extent and mode of inheritance of susceptibility to increased adiposity in FH+. Methods Normoglycaemic participants were categorised either FH+ (≥1 1st degree relative with T2DM, 50F/30M, age 45±14 (SD) yr) or FH− (71F/51M, age 43±14 yr). Log-transformed anthropometric measurements (height, hip and waist circumferences) and lean, bone and fat mass …

Quasquicentennial? 125 Years Of Service To South Dakota!, Vickie L. Mix

Vickie Mix

Changing Cities, Changing Roles: Municipal Developments And The Urban Social Contract In Nineteenth Century Vienna, J. Alexander Killion

J. Alexander Killion

Humans have congregated in urban areas for millennia, but the way in which people have viewed the cities they live in has varied greatly over time. The nineteenth century brought extremely rapid changes in the interactions between people and space, especially in urban areas such as the Austrian capital of Vienna. The experience of Viennese inhabitants during this period is typical of what historian Reinhart Koselleck described as a “denaturalization of historical temporalities,” in which “the relations of time and space have been transformed, at first quite slowly, but in the nineteenth and twentieth centuries, quite decisively.” This rapid transformation …