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Pathways To Blunted Facial Affect In Negative Schizotypy: Social Motivation And Online Cognitive Resources, Tovah M.D. Cowan
Pathways To Blunted Facial Affect In Negative Schizotypy: Social Motivation And Online Cognitive Resources, Tovah M.D. Cowan
LSU Doctoral Dissertations
Schizotypy, a range of personality traits which confer liability for schizophrenia, is associated with significantly diminished social functioning and quality of life. Social dysfunction in all forms of schizotypy, including schizophrenia, is connected to blunted affect, or diminished expressivity, particularly facial expressions which are less frequent, intense, or long than typical. However, the mechanisms and treatments for blunted affect are, as yet, poorly understood and underdeveloped. In this project, two putative mechanisms of blunted affect were explored. The first involves cognitive load capacities, which are diminished in schizotypy, causing blunted affect – individuals do not have the cognitive resources to …
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
LSU Master's Theses
Second-generation antipsychotics (SGAs), such as risperidone, are widely prescribed to children, but the long-term effects of SGA treatment are not well understood. This study investigated the impact of early-life risperidone treatment on sucrose demand in mice in adulthood. Mice were administered risperidone or vehicle from postnatal day (PND) 33 to 60 and trained in adulthood (>PND 120) to nose poke for a sucrose solution reinforcer. The fixed ratio (FR) value (the number of responses required to produce sucrose delivery; the “price” of sucrose) was varied from 1 to 45, and the resulting consumption versus FR value data were analyzed …